Substrate Specificity Combined with Stereopromiscuity in Glutathione Transferase A4-4-Dependent Metabolism of 4-Hydroxynonenal (Q27659040)

2

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Kimberly A Kripps

3

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Laura M Shireman

4

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Ronald E Stenkamp

5

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Wei Zhang

6

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Bengt Mannervik

7

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William M Atkins

Structural Analysis of a Glutathione Transferase A1-1 Mutant Tailored for High Catalytic Efficiency with Toxic Alkenals

8

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language of work or name

English

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publication date

23 February 2010

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published in

Biochemistry

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volume

49

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issue

7

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page(s)

1541-8

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cites work

1 reference

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Localization of the C-terminus of rat glutathione S-transferase A1-1: crystal structure of mutants W21F and W21F/F220Y

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Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface

20 March 2017

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Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

20 March 2017

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Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4

20 March 2017

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Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

20 March 2017

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Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate

20 March 2017

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Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Contribution of aromatic-aromatic interactions to the anomalous pK(a) of tyrosine-9 and the C-terminal dynamics of glutathione S-transferase A1-1

20 March 2017

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Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth

20 March 2017

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20 March 2017

Glutathione transferases

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Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase

7 April 2017

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The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases

29 September 2017

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Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal

29 September 2017

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New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix

29 September 2017

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Mass spectrometry for detection of 4-hydroxy-trans-2-nonenal (HNE) adducts with peptides and proteins.

29 September 2017

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4-hydroxynonenal and neurodegenerative diseases

29 September 2017

1 reference

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Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling

29 September 2017

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The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma

29 September 2017

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A highly acidic tyrosine 9 and a normally titrating tyrosine 212 contribute to the catalytic mechanism of human glutathione transferase A4-4.

29 September 2017

1 reference

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Reengineering the glutathione S-transferase scaffold: a rational design strategy pays off.

29 September 2017

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Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation

29 September 2017

1 reference

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The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress

29 September 2017

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Structure, catalytic mechanism, and evolution of the glutathione transferases

29 September 2017

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Role of lipid aldehydes in cataractogenesis: 4-hydroxynonenal-induced cataract

29 September 2017

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Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1.

29 September 2017

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Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein

29 September 2017

1 reference

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4-Hydroxy-2(E)-nonenal enantiomers: (S)-selective inactivation of glyceraldehyde-3-phosphate dehydrogenase and detoxification by rat glutathione S-transferase A4-4.

2 June 2018

1 reference

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Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases

2 June 2018

1 reference

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Enantioselective metabolism of (R)- and (S)-4-hydroxy-2-nonenal in rat.

27 November 2018

1 reference

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Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases

27 November 2018

1 reference

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Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

27 November 2018

1 reference

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Structural basis of protein-bound endogenous aldehydes. Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829664

Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress

27 November 2018

1 reference

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Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20085333

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20085333