Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation (Q27660497)

2

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Yaya Wang

3

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Genhong Cheng

4

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Hao Wu

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

5

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publication date

9 April 2010

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published in

Molecular Cell

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volume

38

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issue

1

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page(s)

101-13

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cites work

1 reference

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

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Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

20 March 2017

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20 March 2017

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Shape complementarity at protein/protein interfaces

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

20 March 2017

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

20 March 2017

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7 April 2017

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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

7 April 2017

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Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation

29 September 2017

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TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaB.

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Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

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cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand

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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

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A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment

29 September 2017

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Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling

29 September 2017

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29 September 2017

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The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

27 November 2018

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27 November 2018

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The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

27 November 2018

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TRAF1 is a TNF inducible regulator of NF-kappaB activation.

27 November 2018

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TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20385093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20385093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2010.03.009

1 reference

1 reference

1 reference

PubMed publication ID

20385093

1 reference