Functional impact of cancer-associated mutations in the tumor suppressor protein ING4 (Q27664047)

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Alicia Palacios

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Jose Luis Orgaz

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Benilde Jimenez

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Francisco J Blanco

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Ignacio Palmero

Modelling the molecular circuitry of cancer

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language of work or name

English

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publication date

November 2010

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published in

Carcinogenesis

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volume

31

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issue

11

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page(s)

1932-8

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cites work

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ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells

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A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer

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The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angio

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The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

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ING4 induces cell growth inhibition in human lung adenocarcinoma A549 cells by means of Wnt-1/beta-catenin signaling pathway

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Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1.

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Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4.

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The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

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ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation

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Molecular Basis of Histone H3K4me3 Recognition by ING4

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ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation

21 January 2018

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The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes

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Hbo1 Links p53-dependent stress signaling to DNA replication licensing

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Nuclear localization signal of ING4 plays a key role in its binding to p53.

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Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas

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Detection of novel mRNA splice variants of human ING4 tumor suppressor gene.

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Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma

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Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility

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Induction of senescence by oncogenic Ras.

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Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.

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HuntING4 new tumor suppressors

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Role of ING4 in human melanoma cell migration, invasion and patient survival

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Adenovirus-mediated ING4 expression suppresses lung carcinoma cell growth via induction of cell cycle alteration and apoptosis and inhibition of tumor invasion and angiogenesis

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Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4

21 January 2018

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The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

21 January 2018

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Two wobble-splicing events affect ING4 protein subnuclear localization and degradation

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Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor

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Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells

21 January 2018

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The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system

21 January 2018

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HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation

21 January 2018

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Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14.

21 January 2018

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Decreased expression of inhibitor of growth 4 correlated with poor prognosis of hepatocellular carcinoma.

21 January 2018

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A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis

21 January 2018

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Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2

21 January 2018

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