The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system (Q39771199)

14 September 2017

The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system (English)

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ubiquitin-proteasome system

14 September 2017

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author name string

G Chen

1

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14 September 2017

Y Wang

2

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14 September 2017

M Garate

3

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14 September 2017

J Zhou

4

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14 September 2017

G Li

5

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14 September 2017

language of work or name

English

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publication date

23 November 2009

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14 September 2017

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14 September 2017

29

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10

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14 September 2017

1498-1508

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https://scigraph.springernature.com/pub.10.1038/onc.2009.424

14 September 2017

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

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Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells

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NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)

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Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression

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Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer.

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Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers

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MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding

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Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo

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ING3 promotes UV-induced apoptosis via Fas/caspase-8 pathway in melanoma cells.

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Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes

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26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate

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Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship

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Nuclear to cytoplasmic compartment shift of the p33ING1b tumour suppressor protein is associated with malignancy in melanocytic lesions

31 March 2020

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Ubiquitin-independent degradation and its implication in cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.424

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.424

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14 September 2017

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