Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase (Q27664292)

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Language	Label	Description	Also known as
English	Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase	scientific article

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scholarly article

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Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase (English)

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crystal structure

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Acinetobacter baumannii

1 reference

based on heuristic

inferred from title

Focco van den Akker

11

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5

object named as

Jared M Sampson

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Robert A Bonomo

12

object named as

Robert A Bonomo

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Christopher R Bethel

7

object named as

Christopher R Bethel

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8

object named as

Anne M Distler

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Sundar Ram Reddy Pagadala

10

object named as

Sundar Ram Reddy Pagadala

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14

object named as

John D Buynak

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Anjaneyulu Sheri

3

object named as

Anjaneyulu Sheri

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9

object named as

Sarah M Drawz

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author name string

German Bou

1

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Elena Santillana

2

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Alejandro Beceiro

4

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Matthew Kalp

6

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Antonio Romero

13

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language of work or name

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publication date

29 September 2010

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Journal of the American Chemical Society

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132

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13320-31

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38

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Three decades of beta-lactamase inhibitors

1 reference

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Updated functional classification of beta-lactamases

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20 March 2017

Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

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20 March 2017

Strategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE

1 reference

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20 March 2017

Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1

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20 March 2017

Carbapenemases: the versatile beta-lactamases

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20 March 2017

Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis

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20 March 2017

Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis

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20 March 2017

Comparison of -lactamases of classes A and D: 1.5-A crystallographic structure of the class D OXA-1 oxacillinase

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Critical involvement of a carbamylated lysine in catalytic function of class D -lactamases

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20 March 2017

Inhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone

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20 March 2017

The integration of macromolecular diffraction data

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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29 September 2017

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29 September 2017

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29 September 2017

beta-Lactamases- the Threat Renews

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 beta-lactamase: defining a unique family of class C enzymes

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29 September 2017

How beta-lactamases have driven pharmaceutical drug discovery. From mechanistic knowledge to clinical circumvention

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29 September 2017

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29 September 2017

Class C beta-lactamases operate at the diffusion limit for turnover of their preferred cephalosporin substrates

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29 September 2017

The beta-lactamase cycle: a tale of selective pressure and bacterial ingenuity

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29 September 2017

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29 September 2017

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29 September 2017

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27 November 2018

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Outer membrane permeability of Acinetobacter calcoaceticus and its implication in antibiotic resistance

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The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors

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10.1021/JA104092Z

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