Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors (Q27666155)

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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors

Language	Label	Description	Also known as
English	Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors	scientific article	Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors

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scholarly article

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Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors (English)

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high-throughput screening

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12

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4

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Christopher J. Schofield

16

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object named as

Nathan R Rose

5

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object named as

Bryan T Mott

9

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object named as

Ajit Jadhav

13

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17

object named as

Anton Simeonov

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1

object named as

Oliver N F King

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author name string

Xuan Shirley Li

2

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Masaaki Sakurai

3

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Stanley S Ng

6

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Amy M Quinn

7

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Ganesha Rai

8

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Paul Beswick

10

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Robert J Klose

11

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Tom D Heightman

14

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David J Maloney

15

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language of work or name

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publication date

23 November 2010

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5

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e15535

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11

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copyright license

Creative Commons CC0 License

23 November 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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describes a project that uses

object named as

CellProfiler

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Crystal structures of human FIH-1 in complex with quinol family inhibitors

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20 March 2017

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Compound Management for Quantitative High-Throughput Screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Features and development of Coot

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Phasercrystallographic software

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Scaling and assessment of data quality

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Regulation of histone methylation by demethylimination and demethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

20 March 2017

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

7 April 2017

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

7 April 2017

Heterochromatin revisited

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

7 April 2017

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

A miniaturized screen for inhibitors of Jumonji histone demethylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

A robotic platform for quantitative high-throughput screening

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Dynamic protein methylation in chromatin biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

The human oxygen sensing machinery and its manipulation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Fluorescence spectroscopic profiling of compound libraries

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Histone lysine demethylases: emerging roles in development, physiology and disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

29 September 2017

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

2 June 2018

Dynamic states of the DNA repair enzyme AlkB regulate product release

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

2 June 2018

Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

2 June 2018

Inhibition of prolyl hydroxylation and procollagen processing in chick-embryo calvaria by a derivative of pyridine-2,4-dicarboxylate. Characterization of the diethyl ester as a proinhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990756

2 June 2018

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015535

21 January 2018

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21124847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21124847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Spectrophotometric Method for Determining the Oxidative Deamination of Methylamine by the Amine Oxidases

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https://pubmed.ncbi.nlm.nih.gov/21124847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromatin-modifying enzymes as therapeutic targets--Part 1

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https://pubmed.ncbi.nlm.nih.gov/21124847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0015535

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2010PLoSO...515535K

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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