A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells (Q27667168)

1-O-(alpha-D-galactopyranosyl)-N-tetracosanylphytosphingosine

60748

1 reference

1-O-(4-deoxy-alpha-D-xylo-hexopyranosyl)-N-hexacosanoylsphinganine

59446

1 reference

1-O-(alpha-D-galactopyranosyl)-N-hexacosanoylsphinganine

63003

1 reference

1-O-(4-deoxy-alpha-D-xylo-hexopyranosyl)-N-hexacosanoylphytosphingosine

63008

1 reference

1-O-(alpha-D-glucopyranosyl)-N-icosa-11,14-dienoylphytosphingosine

63007

1 reference

63000

alpha-galactosylceramide

1 reference

1-O-(3-deoxy-alpha-D-galactopyranosyl)-N-hexacosanoylsphinganine

466659

1 reference

20

0 references

James McCluskey

16

0 references

Lucy C. Sullivan

Lucy C Sullivan

6

0 references

Amy R. Howell

Amy R Howell

12

0 references

Andrew G Brooks

Andrew G Brooks

14

0 references

Dale I Godfrey

Dale I Godfrey

19

0 references

Gurdyal Besra

Gurdyal S Besra

15

0 references

Laurent Gapin

17

Laurent Gapin

0 references

Steven A Porcelli

18

Steven A Porcelli

0 references

Kwok S Wun

Kwok S Wun

1

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author name string

Garth Cameron

2

0 references

Onisha Patel

3

0 references

Siew Siew Pang

4

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Daniel G Pellicci

5

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Santosh Keshipeddy

7

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Mary H Young

8

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Adam P Uldrich

9

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Meena S Thakur

10

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Stewart K Richardson

11

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Petr A Illarionov

The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode

13

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language of work or name

English

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publication date

25 March 2011

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published in

Immunity

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volume

34

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issue

3

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page(s)

327-39

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cites work

1 reference

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Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by V 14i NKT Cells

20 March 2017

1 reference

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Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands

20 March 2017

1 reference

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Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 and Vβ7 Semi-invariant NKT T Cell Receptors

20 March 2017

1 reference

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Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

20 March 2017

1 reference

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CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor

20 March 2017

1 reference

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A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

20 March 2017

1 reference

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A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

20 March 2017

1 reference

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20 March 2017

The biology of NKT cells

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20 March 2017

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CD1d ligands: the good, the bad, and the ugly

7 April 2017

1 reference

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CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides

20 March 2017

1 reference

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Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.

20 March 2017

1 reference

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Fast on-rates allow short dwell time ligands to activate T cells

29 September 2017

1 reference

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iNKT cell autoreactivity: what is 'self' and how is it recognized?

29 September 2017

1 reference

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TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

29 September 2017

1 reference

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Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

29 September 2017

1 reference

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Antigen recognition by CD1d-restricted NKT T cell receptors.

29 September 2017

1 reference

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Lipid and glycolipid antigens of CD1d-restricted natural killer T cells

29 September 2017

1 reference

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Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire

29 September 2017

1 reference

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Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer

29 September 2017

1 reference

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Harnessing invariant NKT cells in vaccination strategies

29 September 2017

1 reference

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A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

The fidelity, occasional promiscuity, and versatility of T cell receptor recognition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

Invariant and noninvariant natural killer T cells exert opposite regulatory functions on the immune response during murine schistosomiasis

29 September 2017

1 reference

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A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.

29 September 2017

1 reference

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Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides

29 September 2017

1 reference

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Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide

29 September 2017

1 reference

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Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected].

29 September 2017

1 reference

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Molecular interactions mediating T cell antigen recognition

29 September 2017

1 reference

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Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers

29 September 2017

1 reference

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Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

29 September 2017

1 reference

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Synthesis and biological activity of alpha-glucosyl C24:0 and C20:2 ceramides

29 September 2017

1 reference

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Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.

2 June 2018

1 reference

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Germline-encoded recognition of diverse glycolipids by natural killer T cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

NKT cells: what's in a name?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745

Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064745