Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons (Q27671836)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21854986%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Structural linkage between ligand discrimination and receptor activation by type I interferons (English)

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1

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Garry P Nolan

1 reference

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11 February 2020

Ignacio Moraga

2

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ORCID Public Data File 2021

author name string

Doron Levin

3

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11 February 2020

Peter O Krutzik

4

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Yulia Podoplelova

5

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11 February 2020

Angelica Trejo

6

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11 February 2020

Choongho Lee

7

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11 February 2020

Ganit Yarden

8

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Susan E Vleck

9

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Jeffrey S Glenn

10

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Jacob Piehler

12

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Gideon Schreiber

13

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K Christopher Garcia

14

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11 February 2020

language of work or name

English

0 references

publication date

1 August 2011

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11 February 2020

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11 February 2020

volume

146

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11 February 2020

page(s)

621-632

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issue

4

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Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1

11 February 2020

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Intermolecular Interactions in a 44 kDa Interferon−Receptor Complex Detected by Asymmetric Reverse-Protonation and Two-Dimensional NOESY

20 March 2017

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Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

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Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

20 March 2017

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Structure of IL-22 bound to its high-affinity IL-22R1 chain

20 March 2017

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The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding

20 March 2017

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Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site

20 March 2017

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Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography

20 March 2017

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20 March 2017

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Automated structure solution with autoSHARP

20 March 2017

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Virus interference. I. The interferon

20 March 2017

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Interferons at age 50: past, current and future impact on biomedicine

20 March 2017

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The receptor of the type I interferon family

20 March 2017

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Interferons, interferon-like cytokines, and their receptors

20 March 2017

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Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor

20 March 2017

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Stochastic receptor expression determines cell fate upon interferon treatment

20 March 2017

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Structural analysis of cytokines comprising the IL-10 family

29 September 2017

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Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B.

29 September 2017

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Receptor density is key to the alpha2/beta interferon differential activities.

29 September 2017

1 reference

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Structural biology of shared cytokine receptors

29 September 2017

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Inteferons pen the JAK-STAT pathway

29 September 2017

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An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities

29 September 2017

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Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex

29 September 2017

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Complex modulation of cell type-specific signaling in response to type I interferons

29 September 2017

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Type 1 interferons and the virus-host relationship: a lesson in détente .

29 September 2017

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Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta

29 September 2017

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Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.

29 September 2017

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Functional cartography of the ectodomain of the type I interferon receptor subunit ifnar1.

29 September 2017

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Structural analysis of IL-10 and Type I interferon family members and their complexes with receptor

29 September 2017

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Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity

29 September 2017

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Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking

29 September 2017

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New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface

29 September 2017

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The function of type I interferons in antimicrobial immunity.

29 September 2017

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The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling

29 September 2017

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Differential receptor subunit affinities of type I interferons govern differential signal activation.

2 June 2018

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Antitumor effects of interferon-omega: in vivo therapy of human tumor xenografts in nude mice.

2 June 2018

1 reference

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The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.

2 June 2018

1 reference

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Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.

27 November 2018

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Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site.

27 November 2018

1 reference

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Hydrophobic cluster analysis reveals duplication in the external structure of human alpha-interferon receptor and homology with gamma-interferon receptor external domain

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21854986

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21854986

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2011.06.048

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4011693

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21854986%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

11 February 2020

4011693

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21854986%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference