Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1 (Q27672807)

7

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David R. Spring

object named as

David R Spring

5

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author name string

Yaw Sing Tan

1

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Paweł Śledź

2

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Steffen Lang

3

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Christopher J Stubbs

Angewandte Chemie International Edition

4

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language of work or name

English

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publication date

1 October 2012

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published in

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volume

51

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page(s)

10078-81

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issue

40

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cites work

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Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

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Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

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From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

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Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors

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Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures

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Locally accessible conformations of proteins: multiple molecular dynamics simulations of crambin

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Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery

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Targeting polo-like kinase 1 for cancer therapy.

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Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase

21 January 2018

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ANIE.201205676

1 reference

877404

877404

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1 reference

1 reference