Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein (Q42451287)

31 October 2017

Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein (English)

1 reference

31 October 2017

Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein (English)

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https://api.crossref.org/works/10.1074/JBC.M308175200

20 March 2024

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20 March 2024

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20 March 2024

3

Hiroshi Omote

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20 March 2024

author name string

Marwan K. Al-Shawi

1

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20 March 2024

Mark K. Polar

2

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20 March 2024

Robert A. Figler

4

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20 March 2024

language of work or name

English

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publication date

9 October 2003

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full work available at URL

31 October 2017

http://www.jbc.org/article/S0021925820752750/pdf

file format

Portable Document Format

online access status

open access

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https://api.elsevier.com/content/article/PII:S0021925820752750?httpAccept=text/xml

20 March 2024

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https://api.elsevier.com/content/article/PII:S0021925820752750?httpAccept=text/plain

20 March 2024

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https://syndication.highwire.org/content/doi/10.1074/jbc.M308175200

20 March 2024

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Journal of Biological Chemistry

20 March 2024

published in

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31 October 2017

278

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31 October 2017

52

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31 October 2017

52629-52640

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

31 October 2017

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Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

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The catalytic cycle of P-glycoprotein

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Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

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Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity

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Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

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P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity

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Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

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Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

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Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

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Use of chemical chaperones in the yeast Saccharomyces cerevisiae to enhance heterologous membrane protein expression: high-yield expression and purification of human P-glycoprotein

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ATPase activity of Chinese hamster P-glycoprotein

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A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein

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Rotational coupling in the F0F1 ATP synthase

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Functional Co-expression of the canine cardiac Ca2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPase regulation

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The Escherichia coli FOF1 gammaM23K uncoupling mutant has a higher K0.5 for Pi. Transition state analysis of this mutant and others reveals that synthesis and hydrolysis utilize the same kinetic pathway

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Determination of microgram quantities of protein in the presence of milligram levels of lipid with amido black 10B.

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The P-glycoprotein efflux pump: how does it transport drugs?

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An extended kinetic analysis of valinomycin-induced Rb-transport through monoglyceride membranes

21 January 2018

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Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

21 January 2018

1 reference

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Characterization of two pharmacophores on the multidrug transporter P-glycoprotein

21 January 2018

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Linear and cyclic peptides as substrates and modulators of P-glycoprotein: peptide binding and effects on drug transport and accumulation

21 January 2018

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

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A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.

21 January 2018

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Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein

21 January 2018

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The ATPase and ATP-binding functions of P-glycoprotein--modulation by interaction with defined phospholipids

21 January 2018

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21 January 2018

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The effects of lipids and detergents on ATPase-active P-glycoprotein

21 January 2018

1 reference

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Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

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Energy coupling, turnover, and stability of the F0F1 ATP synthase are dependent on the energy of interaction between gamma and beta subunits

21 January 2018

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Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase--further experimental evidence for a multisite model

21 January 2018

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HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity.

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Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP

21 January 2018

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Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

21 January 2018

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ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells.

21 January 2018

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Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.

21 January 2018

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Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates

21 January 2018

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The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

21 January 2018

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Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

21 January 2018

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Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transporters

21 January 2018

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P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state

21 January 2018

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Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1.

21 January 2018

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Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.

21 January 2018

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The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover

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Biochemistry of multidrug resistance mediated by the multidrug transporter

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Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

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Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

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Inorganic and organic phosphate measurements in the nanomolar range

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ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines

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Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity

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Complete kinetic and thermodynamic characterization of the unisite catalytic pathway of Escherichia coli F1-ATPase. Comparison with mitochondrial F1-ATPase and application to the study of mutant enzymes.

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The role of passive transbilayer drug movement in multidrug resistance and its modulation

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Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

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Co-operating ATP sites in the multiple drug resistance transporter Mdr1

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Interaction of P-glycoprotein with defined phospholipid bilayers: a differential scanning calorimetric study

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Identifiers

1 reference

31 October 2017

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