Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein (Q44746508)

5 December 2017

Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein (English)

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5 December 2017

transmembrane protein

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author

Tip W. Loo

series ordinal

1

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5 December 2017

M Claire Bartlett

2

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PubMed ID

14749322

5 December 2017

David M Clarke

series ordinal

3

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PubMed ID

14749322

5 December 2017

language of work or name

English

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publication date

28 January 2004

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Journal of Biological Chemistry

5 December 2017

7

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based on heuristic

inferred from page(s)

published in

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5 December 2017

279

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5 December 2017

18232-18238

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5 December 2017

18

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Multidrug resistance in cancer: role of ATP-dependent transporters

5 December 2017

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Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance

21 January 2018

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

21 January 2018

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The human ATP-binding cassette (ABC) transporter superfamily

21 January 2018

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

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The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

1 reference

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P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

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The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

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Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

21 January 2018

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A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein

21 January 2018

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Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

21 January 2018

1 reference

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Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

21 January 2018

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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

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Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

21 January 2018

1 reference

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Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

21 January 2018

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Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

21 January 2018

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Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

21 January 2018

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Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

21 January 2018

1 reference

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

1 reference

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P-glycoprotein. Associations between domains and between domains and molecular chaperones

21 January 2018

1 reference

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Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

21 January 2018

1 reference

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Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

21 January 2018

1 reference

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Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

21 January 2018

1 reference

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Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

21 January 2018

1 reference

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Mutational analysis of human P-glycoprotein.

21 January 2018

1 reference

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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

1 reference

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

21 January 2018

1 reference

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Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

21 January 2018

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A structural model for the open conformation of the mdr1 P-glycoprotein based on the MsbA crystal structure

21 January 2018

1 reference

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Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains

21 January 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

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Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

1 reference

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

1 reference

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An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

21 January 2018

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Molecular dissection of the human multidrug resistance P-glycoprotein

21 January 2018

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Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

21 January 2018

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Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

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Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

21 January 2018

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Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

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Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

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Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

21 January 2018

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Myosin active-site trapping with vanadate ion

21 January 2018

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A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M400229200

1 reference

5 December 2017

1 reference

PubMed ID

14749322