A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands (Q27675663)

1

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Peter Trenh

2

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Rebecca L Smith

3

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Bianca Bautista

4

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Priya G Huseby

5

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Guoqi Li

6

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Lawrence J Stern

7

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Eric S Huseby

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

8

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language of work or name

English

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publication date

23 November 2011

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published in

Immunity

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volume

35

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issue

5

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page(s)

694-704

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cites work

1 reference

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Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

20 March 2017

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Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 and Vβ7 Semi-invariant NKT T Cell Receptors

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Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

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Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids

20 March 2017

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The molecular basis of TCR germline bias for MHC is surprisingly simple

20 March 2017

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20 March 2017

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20 March 2017

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7 April 2017

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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

7 April 2017

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Fast on-rates allow short dwell time ligands to activate T cells

29 September 2017

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Structural alterations in peptide-MHC recognition by self-reactive T cell receptors

29 September 2017

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29 September 2017

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Evolutionarily conserved amino acids that control TCR-MHC interaction

29 September 2017

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Structural determinants of T-cell receptor bias in immunity

29 September 2017

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Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

29 September 2017

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29 September 2017

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Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity

29 September 2017

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Back to central tolerance

29 September 2017

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29 September 2017

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What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?

29 September 2017

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29 September 2017

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Diverse TCRs recognize murine CD1.

29 September 2017

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How many thymocytes audition for selection?

29 September 2017

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The MHC reactivity of the T cell repertoire prior to positive and negative selection.

29 September 2017

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Mouse T-cell receptor variable gene segment families

29 September 2017

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Development and selection of T cells: facts and puzzles

29 September 2017

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29 September 2017

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Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c.

29 September 2017

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Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

29 September 2017

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Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire

29 September 2017

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29 September 2017

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Correlations between T-cell specificity and the structure of the antigen receptor.

29 September 2017

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High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

2 June 2018

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A T cell receptor V alpha region selectively expressed in CD4+ cells

2 June 2018

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Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

2 June 2018

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Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8+ T cells.

19 June 2018

1 reference

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27 November 2018

The IMGT/HLA database

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CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications

27 November 2018

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How the T Cell Repertoire Becomes Peptide and MHC Specific

27 November 2018

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The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

27 November 2018

1 reference

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Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

27 November 2018

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V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition

27 November 2018

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Processing of X-ray diffraction data collected in oscillation mode

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T cell tolerance by clonal elimination in the thymus

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Binding of immunogenic peptides to Ia histocompatibility molecules

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Positive selection of thymocytes

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Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

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12 December 2020

10.1016/J.IMMUNI.2011.10.012

Identifiers

DOI

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2059789

2059789

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1 reference

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