A Strategy for Modulation of Enzymes in the Ubiquitin System (Q27675727)

24

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Sirano Dhe-Paganon

31

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Masoud Vedadi

21

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Daniel Durocher

26

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Elton Zeqiraj

18

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Daniela Rotin

28

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Abdellah Allali-Hassani

20

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Andreas Ernst

object named as

Andreas Ernst

1

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author name string

George Avvakumov

2

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Jiefei Tong

3

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Yihui Fan

4

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Yanling Zhao

5

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Philipp Alberts

6

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Avinash Persaud

7

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John R Walker

8

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Ana-Mirela Neculai

9

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Dante Neculai

10

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Andrew Vorobyov

11

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Pankaj Garg

12

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Linda Beatty

13

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Pak-Kei Chan

14

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Yu-Chi Juang

15

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Marie-Claude Landry

16

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Christina Yeh

17

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Konstantina Karamboulas

19

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Mike Tyers

22

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Jason Moffat

23

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Laurence Pelletier

25

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Brian Raught

27

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Jianhua Yang

29

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Michael F Moran

30

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Sachdev S Sidhu

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

32

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language of work or name

English

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publication date

1 February 2013

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published in

Science

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volume

339

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page(s)

590-5

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issue

6119

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Structural basis and specificity of human otubain 1-mediated deubiquitination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Breaking the chains: structure and function of the deubiquitinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

E2s: structurally economical and functionally replete

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Targeting ubiquitin specific proteases for drug discovery

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

A genomic and functional inventory of deubiquitinating enzymes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

A dynamic role of HAUSP in the p53-Mdm2 pathway

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Phasercrystallographic software

20 March 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230161

Coot: model-building tools for molecular graphics

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230161

Refinement of macromolecular structures by the maximum-likelihood method

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230161

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230161

SuperPose: a simple server for sophisticated structural superposition

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230161

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230161

ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230161

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Ubiquitin-binding domains

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Ubiquitin: structures, functions, mechanisms

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

TANDEM: matching proteins with tandem mass spectra

7 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

NCBI Reference Sequences: current status, policy and new initiatives

22 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1.

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Will the ubiquitin system furnish as many drug targets as protein kinases?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

The therapeutic potential of deubiquitinating enzyme inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

The emerging complexity of protein ubiquitination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Targeting the ubiquitin-proteasome system for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Polyubiquitin chains: functions, structures, and mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

The isopeptidase USP2a protects human prostate cancer from apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Derivitization of the C-terminus of ubiquitin and ubiquitin-like proteins using intein chemistry: methods and uses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

Phage display for selection of novel binding peptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

ERBB2 is a target for USP8-mediated deubiquitination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815447

High-throughput biotinylation of proteins

2 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

ProteoWizard: open source software for rapid proteomics tools development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

ProHits: integrated software for mass spectrometry-based interaction proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230161

HAUSP is required for p53 destabilization

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23287719

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23287719

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23287719