Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors (Q27676712)

From Wikidata

Jump to navigation Jump to search

scientific article

Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors

Language	Label	Description	Also known as
English	Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors	scientific article	Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors

Statements

scholarly article

0 references

Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors (English)

0 references

Trypanosoma cruzi

0 references

1 reference

based on heuristic

inferred from title

Alejandro Buschiazzo

1

0 references

object named as

Juan Mucci

5

0 references

Oscar Campetella

object named as

Oscar Campetella

6

0 references

author name string

Romina Muiá

2

0 references

Nicole Larrieux

3

0 references

Tamara Pitcovsky

4

0 references

language of work or name

0 references

publication date

January 2012

0 references

0 references

8

0 references

1

0 references

e1002474

0 references

copyright license

Creative Commons Attribution 4.0 International

5 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

MolProbity: all-atom structure validation for macromolecular crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

The thymus is a common target organ in infectious diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

Structural basis of sialyltransferase activity in trypanosomal sialidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

Phasercrystallographic software

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

Shape complementarity at protein/protein interfaces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R&D; pipeline challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

A novel cell surface trans-sialidase of trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

7 April 2017

Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

DARPins: a new generation of protein therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Engineered antibody fragments and the rise of single domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

A superfamily of Trypanosoma cruzi surface antigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Enzymically inactive members of the trans-sialidase family from Trypanosoma cruzi display beta-galactose binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Mammalian cell sialic acid enhances invasion by Trypanosoma cruzi.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Immunobiology of murine T. cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Antibody-antigen complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

29 September 2017

Quantitation of picomole levels of N-acetyl- and N-glycolylneuraminic acids by a HPLC-adaptation of the thiobarbituric acid assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

2 June 2018

Serum neuraminidase activity and hematological alterations in acute human Chagas' disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

2 June 2018

Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Improving protein pharmacokinetics by genetic fusion to simple amino acid sequences

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Differential expression of a virulence factor, the trans-sialidase, by the main Trypanosoma cruzi phylogenetic lineages

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

A functional network of intramolecular cross-reacting epitopes delays the elicitation of neutralizing antibodies to Trypanosoma cruzi trans-sialidase.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Long-lasting antibodies detected by a trans-sialidase inhibition assay of sera from parasite-free, serologically cured chagasic patients

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

A single tyrosine differentiates active and inactive Trypanosoma cruzi trans-sialidases.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

An epidemiologically significant epitope of a 1998 human influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

The trans-sialidase from the african trypanosome Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

The urgent need to develop new drugs and tools for the treatment of Chagas disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

27 November 2018

Immune system pathogenesis is prevented by the neutralization of the systemic trans-sialidase from Trypanosoma cruzi during severe infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

27 November 2018

Connective Tissue Reactions in Normal and Immunized Mice to a Reticulotropic Strain of Trypanosoma Cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

27 November 2018

The repetitive domain of Trypanosoma cruzi trans-sialidase enhances the immune response against the catalytic domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

27 November 2018

Medium scale production and purification to homogeneity of a recombinant trans-sialidase from Trypanosoma cruzi.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

27 November 2018

Role of sialic acid in the resistance of Trypanosoma cruzi trypomastigotes to complement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

27 November 2018

Antibodies inhibiting Trypanosoma cruzi trans-sialidase activity in sera from human infections

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252381

27 November 2018

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

The trans-sialidase of Trypanosoma cruzi is anchored by two different lipids

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

trans‐Sialidase fromTrypanosoma cruziInduces Apoptosis in Cells from the Immune System In Vivo

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Immune system pathogenesis is prevented by the neutralization of the systemic trans-sialidase from Trypanosoma cruzi during severe infections

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002474

21 January 2018

Incorporation of sialic acid into Trypanosoma cruzi macromolecules. A proposal for a new metabolic route

1 reference

https://pubmed.ncbi.nlm.nih.gov/22241998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against lethal influenza with neuraminidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22241998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q27676712&oldid=1868418600"