Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor (Q27677383)

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English	Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor	scientific article

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Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor (English)

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Mutsuko Kukimoto-Niino

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M Kukimoto-Niino

2

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Shigeyuki Yokoyama

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S Yokoyama

20

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author name string

S Yoshikawa

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L Parker

3

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N Handa

4

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T Terada

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T Fujimoto

6

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Y Terazawa

7

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M Wakiyama

8

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M Sato

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S Sano

10

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T Kobayashi

11

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T Tanaka

12

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L Chen

13

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Z-J Liu

14

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B-C Wang

15

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M Shirouzu

16

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S Kawa

17

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K Semba

18

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T Yamamoto

19

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language of work or name

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publication date

3 January 2013

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32

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27-38

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Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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Activation of tyrosine kinases by mutation of the gatekeeper threonine

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion

1 reference

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Discovery of a novel Her-1/Her-2 dual tyrosine kinase inhibitor for the treatment of Her-1 selective inhibitor-resistant non-small cell lung cancer

1 reference

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The CCP4 suite: programs for protein crystallography

1 reference

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

1 reference

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A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib

1 reference

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Sequence and structure signatures of cancer mutation hotspots in protein kinases

1 reference

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Coot: model-building tools for molecular graphics

1 reference

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PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib

1 reference

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Investigations on protein crystal growth by the gel acupuncture method

1 reference

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Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

1 reference

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Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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A solution for the best rotation to relate two sets of vectors

1 reference

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Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1 reference

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The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor

1 reference

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

1 reference

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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

1 reference

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BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

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https://api.crossref.org/works/10.1038%2FONC.2012.21

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Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

1 reference

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

1 reference

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Pushing the boundaries of molecular replacement with maximum likelihood

1 reference

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Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation

1 reference

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MOLREP: an Automated Program for Molecular Replacement

1 reference

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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.21

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Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

1 reference

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LAFIRE: software for automating the refinement process of protein-structure analysis.

1 reference

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

1 reference

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

1 reference

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

1 reference

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Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

1 reference

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Discovery of selective irreversible inhibitors for EGFR-T790M.

1 reference

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Antitumor activity of HM781-36B, a highly effective pan-HER inhibitor in erlotinib-resistant NSCLC and other EGFR-dependent cancer models

1 reference

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31 March 2020

A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src

1 reference

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A novel treatment strategy for EGFR mutant NSCLC with T790M-mediated acquired resistance

1 reference

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