Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel (Q27677407)

7

0 references

Pierre-Jean Corringer

5

0 references

Rebecca J Howard

object named as

Rebecca J Howard

2

0 references

author name string

Ludovic Sauguet

1

0 references

Laurie Malherbe

3

0 references

Ui S Lee

4

0 references

R Adron Harris

A locally closed conformation of a bacterial pentameric proton-gated ion channel

6

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language of work or name

English

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publication date

2013

0 references

published in

Nature Communications

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volume

4

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page(s)

1697

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cites work

1 reference

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X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

20 March 2017

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Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

20 March 2017

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A discrete alcohol pocket involved in GIRK channel activation

20 March 2017

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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

20 March 2017

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Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

20 March 2017

1 reference

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GABRG1 and GABRA2 as independent predictors for alcoholism in two populations

20 March 2017

1 reference

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X-ray structure of a prokaryotic pentameric ligand-gated ion channel

20 March 2017

1 reference

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Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster

20 March 2017

1 reference

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Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes

20 March 2017

1 reference

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20 March 2017

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20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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20 March 2017

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Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms

20 March 2017

1 reference

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Theory and simulation of ion conduction in the pentameric GLIC channel

7 April 2017

1 reference

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Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog

29 September 2017

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Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

29 September 2017

1 reference

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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

29 September 2017

1 reference

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Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

29 September 2017

1 reference

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Global burden of disease in young people aged 10-24 years: a systematic analysis

29 September 2017

1 reference

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Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor

29 September 2017

1 reference

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Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels

29 September 2017

1 reference

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Binding, activation and modulation of Cys-loop receptors.

29 September 2017

1 reference

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Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel

29 September 2017

1 reference

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Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding

29 September 2017

1 reference

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The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress

29 September 2017

1 reference

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Ethanol's molecular targets

29 September 2017

1 reference

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Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?

29 September 2017

1 reference

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Inhibitory ligand-gated ion channels as substrates for general anesthetic actions

29 September 2017

1 reference

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A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

29 September 2017

1 reference

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Nicotine addiction and comorbidity with alcohol abuse and mental illness

29 September 2017

1 reference

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Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium

29 September 2017

1 reference

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Improved helix and kink characterization in membrane proteins allows evaluation of kink sequence predictors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Dual action of n-alcohols on neuronal nicotinic acetylcholine receptors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Alcohol in the western world.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

Glycine enhances the central depressant properties of ethanol in mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204805

The interaction between ethanol and cysteine on the central depressant effects of ethanol in mice

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23591864

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HOLLOW: generating accurate representations of channel and interior surfaces in molecular structures

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23591864

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS2682

1 reference

Dimensions Publication ID

ADS bibcode

2013NatCo...4.1697S

0 references

1011990989

0 references

1 reference

1 reference

PubMed publication ID

23591864

1 reference