Structural basis for telmisartan-mediated partial activation of PPAR gamma (Q27677426)

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Tomohiko Yamaguchi

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Kazuki Ohno

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Tatsuya Niimi

4

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Masaya Orita

5

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Hitoshi Sakashita

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Makoto Takeuchi

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

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publication date

July 2012

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published in

Hypertension Research

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volume

35

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page(s)

715-9

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issue

7

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cites work

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Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity

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An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes.

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Angiotensin II receptor blockers downsize adipocytes in spontaneously type 2 diabetic rats with visceral fat obesity.

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Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b

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Partial agonists activate PPARgamma using a helix 12 independent mechanism

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A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones

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inferred from DOI database lookup

7 January 2021

based on heuristic

The effects of irbesartan and telmisartan on metabolic parameters and blood pressure in obese, insulin resistant, hypertensive patients

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inferred from DOI database lookup

7 January 2021

based on heuristic

Effects of telmisartan on fat distribution in individuals with the metabolic syndrome

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