Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation (Q27679183)

Vascular endothelial growth factor C

GOA release 2020-03-11

1 reference

vascular endothelial growth factor receptor signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

11

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Veli-Matti Leppänen

1

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Michael Jeltsch

5

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Kurt Ballmer-Hofer

10

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author name string

Denis Tvorogov

2

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Kaisa Kisko

3

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Andrea E Prota

4

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Andrey Anisimov

6

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Sandra Markovic-Mueller

7

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Edward Stuttfeld

8

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Kenneth N Goldie

Proceedings of the National Academy of Sciences of the United States of America

9

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language of work or name

English

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publication date

6 August 2013

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published in

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volume

110

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issue

32

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page(s)

12960-5

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cites work

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Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

20 March 2017

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Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

20 March 2017

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Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

20 March 2017

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Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

20 March 2017

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Cell signaling by receptor tyrosine kinases

20 March 2017

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Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

20 March 2017

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Structural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1D2: RECOGNITION AND SPECIFICITY

20 March 2017

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VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

20 March 2017

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Structural determinants of growth factor binding and specificity by VEGF receptor 2

20 March 2017

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20 March 2017

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Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

20 March 2017

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Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases

20 March 2017

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Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

20 March 2017

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The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1

20 March 2017

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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

20 March 2017

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Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

20 March 2017

1 reference

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Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4

20 March 2017

1 reference

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Automated structure solution with autoSHARP

20 March 2017

1 reference

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Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

20 March 2017

1 reference

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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

20 March 2017

1 reference

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Cardiovascular failure in mouse embryos deficient in VEGF receptor-3

20 March 2017

1 reference

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Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors

20 March 2017

1 reference

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Angiogenesis as a therapeutic target

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

The lymphatic vasculature in disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

An antibody targeted to VEGFR-2 Ig domains 4-7 inhibits VEGFR-2 activation and VEGFR-2-dependent angiogenesis without affecting ligand binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Lymphangiogenesis: Molecular mechanisms and future promise

29 September 2017

1 reference

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Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Analysis of X-ray and neutron scattering from biomacromolecular solutions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Vascular endothelial growth factor: basic science and clinical progress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Forced unfolding modulated by disulfide bonds in the Ig domains of a cell adhesion molecule.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Structure of a VEGF-VEGF receptor complex determined by electron microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740881

Mapping of the Sites Involved in Ligand Association and Dissociation at the Extracellular Domain of the Kinase Insert Domain-containing Receptor for Vascular Endothelial Growth Factor

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23878260

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Signal transduction by vascular endothelial growth factor receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23878260

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1301415110

1 reference

ADS bibcode

2013PNAS..11012960L

0 references

1 reference

1 reference

PubMed publication ID

23878260

1 reference