Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent (Q27679191)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23882082%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent (English)

1 reference

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5 March 2020

1 reference

1

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5 March 2020

author name string

Xiaolei Ma

2

1 reference

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5 March 2020

Henry R Maun

3

1 reference

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5 March 2020

Zhong Zheng

4

1 reference

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5 March 2020

Jing Peng

5

1 reference

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5 March 2020

Mally Romero

6

1 reference

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5 March 2020

Arthur Huang

7

1 reference

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5 March 2020

Nai-ying Yang

8

1 reference

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5 March 2020

Merry Nishimura

9

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5 March 2020

Joan Greve

10

1 reference

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5 March 2020

Lydia Santell

11

1 reference

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5 March 2020

Yu-Wen Zhang

12

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5 March 2020

Yanli Su

13

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5 March 2020

Dafna W Kaufman

14

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5 March 2020

Karen L Billeci

15

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5 March 2020

Elaine Mai

16

1 reference

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5 March 2020

Barbara Moffat

17

1 reference

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5 March 2020

Amy Lim

18

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5 March 2020

Eileen T Duenas

19

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5 March 2020

Heidi S Phillips

20

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5 March 2020

Hong Xiang

21

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5 March 2020

Judy C Young

22

1 reference

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5 March 2020

George F Vande Woude

23

1 reference

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5 March 2020

Mark S Dennis

24

1 reference

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5 March 2020

Dorothea E Reilly

25

1 reference

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5 March 2020

Ralph H Schwall

26

1 reference

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5 March 2020

Melissa A Starovasnik

27

1 reference

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5 March 2020

Robert A Lazarus

28

1 reference

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5 March 2020

Daniel G Yansura

29

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language of work or name

English

0 references

publication date

23 July 2013

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

5 March 2020

published in

1 reference

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5 March 2020

volume

110

1 reference

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5 March 2020

issue

32

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5 March 2020

page(s)

E2987-96

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

5 March 2020

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20 March 2017

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Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution

20 March 2017

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

20 March 2017

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MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

20 March 2017

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A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo

20 March 2017

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20 March 2017

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Met, metastasis, motility and more

7 April 2017

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Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

20 March 2017

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Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies

20 March 2017

1 reference

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Targeting MET in cancer: rationale and progress

29 September 2017

1 reference

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Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies

29 September 2017

1 reference

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Structural insights into Met receptor activation

29 September 2017

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Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody

29 September 2017

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Development trends for human monoclonal antibody therapeutics

29 September 2017

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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.

29 September 2017

1 reference

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Overexpression of TrkB promotes the progression of colon cancer

29 September 2017

1 reference

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Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells

29 September 2017

1 reference

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High-grade glioma mouse models and their applicability for preclinical testing

29 September 2017

1 reference

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c-Met is essential for wound healing in the skin

29 September 2017

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Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities.

29 September 2017

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Somatic mutations lead to an oncogenic deletion of met in lung cancer

29 September 2017

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Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.

29 September 2017

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Met provides essential signals for liver regeneration

29 September 2017

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High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold

29 September 2017

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Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

29 September 2017

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Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

29 September 2017

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Glioblastoma cells release factors that disrupt blood-brain barrier features

29 September 2017

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An efficient route to human bispecific IgG.

29 September 2017

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Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF.

29 September 2017

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An in vivo pathway for disulfide bond isomerization in Escherichia coli

29 September 2017

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The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

29 September 2017

1 reference

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Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.

29 September 2017

1 reference

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Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries

29 September 2017

1 reference

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Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)

29 September 2017

1 reference

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Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

29 September 2017

1 reference

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Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding

29 September 2017

1 reference

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A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis

29 September 2017

1 reference

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From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta(2)-adrenoceptor antibody behave as antagonists

29 September 2017

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Antibody-antigen interactions: contact analysis and binding site topography.

2 June 2018

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Scatter factor and hepatocyte growth factor: activities, properties, and mechanism

2 June 2018

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Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing.

2 June 2018

1 reference

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The Sema domain of Met is necessary for receptor dimerization and activation

21 January 2018

1 reference

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Effective use of thalidomide in the treatment of recurrent metastatic chordoma

21 January 2018

1 reference

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Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1302725110

Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors

21 January 2018

1 reference

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Enhanced growth of human met-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor

21 January 2018

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

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Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors.

21 January 2018

1 reference

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Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1.

27 November 2018

1 reference

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Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis

27 November 2018

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12 December 2020

Somatic cell hybridization of mouse myeloma cells

1 reference

12 December 2020

'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

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12 December 2020

Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and alpha(v)beta3 integrins

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1302725110

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23882082%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

ADS bibcode

2013PNAS..110E2987M

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23882082%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23882082%20AND%20SRC:MED&resulttype=core&format=json