Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus (Q27680467)

2

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Jeffrey A Bell

3

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Woody Sherman

4

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Jeanne A Hardy

Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult Volunteers

5

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publication date

20 December 2013

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published in

ACS Chemical Biology

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volume

8

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issue

12

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page(s)

2744-52

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cites work

1 reference

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Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

20 March 2017

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CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

20 March 2017

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Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen

20 March 2017

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A Tetravalent Dengue Vaccine Based on a Complex Adenovirus Vector Provides Significant Protection in Rhesus Monkeys against All Four Serotypes of Dengue Virus

20 March 2017

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Structural insight into distinct mechanisms of protease inhibition by antibodies

20 March 2017

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Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

20 March 2017

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Site-directed ligand discovery

20 March 2017

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In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3

20 March 2017

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Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins

20 March 2017

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Flavivirus enzyme-substrate interactions studied with chimeric proteinases: identification of an intragenic locus important for substrate recognition

20 March 2017

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Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease

20 March 2017

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

20 March 2017

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Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity

20 March 2017

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Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

20 March 2017

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Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein

7 April 2017

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NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

7 April 2017

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29 September 2017

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Diversity of allosteric regulation in proteases

29 September 2017

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29 September 2017

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NS4A and NS4B proteins from dengue virus: membranotropic regions

29 September 2017

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Protease inhibitors for the treatment of chronic hepatitis C genotype-1 infection: the new standard of care

29 September 2017

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Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease.

29 September 2017

1 reference

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Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target

29 September 2017

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Structural and mechanistic insight into how antibodies inhibit serine proteases.

29 September 2017

1 reference

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Strategies for development of Dengue virus inhibitors

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29 September 2017

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Progress towards a dengue vaccine

29 September 2017

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A re-evaluation of the mechanisms leading to dengue hemorrhagic fever

29 September 2017

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29 September 2017

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Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis

29 September 2017

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Promiscuous aggregate-based inhibitors promote enzyme unfolding

29 September 2017

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Allosteric regulation of proteases

29 September 2017

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Hemophagocytic syndrome in Dengue hemorrhagic fever with severe multiorgan complications.

29 September 2017

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The demand for a dengue vaccine: a contingent valuation survey in Metro Manila

29 September 2017

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HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

29 September 2017

1 reference

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The pathology of dengue hemorrhagic fever

29 September 2017

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29 September 2017

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The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner

29 September 2017

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Dengue virus RNA polymerase NS5: a potential therapeutic target?

29 September 2017

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Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA.

29 September 2017

1 reference

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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

29 September 2017

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29 September 2017

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29 September 2017

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