Structural and Functional Analysis of G Protein-Coupled Receptor Kinase Inhibition by Paroxetine and a Rationally Designed Analog (Q27680587)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24220010%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Kristoff T Homan

1

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6 June 2020

Emily Wu

2

1 reference

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6 June 2020

Michael W Wilson

3

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6 June 2020

Puja Singh

4

1 reference

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6 June 2020

Scott D Larsen

5

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6 June 2020

publication date

February 2014

0 references

published in

Molecular Pharmacology

1 reference

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6 June 2020

volume

85

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6 June 2020

issue

2

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6 June 2020

page(s)

237-248

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Carbon-oxygen hydrogen bonding in biological structure and function

6 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain

20 March 2017

1 reference

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Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

1 reference

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Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation

20 March 2017

1 reference

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

20 March 2017

1 reference

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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

20 March 2017

1 reference

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Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Overview of the CCP4 suite and current developments

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Phasercrystallographic software

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Purification and characterization of the beta-adrenergic receptor kinase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Purification and characterization of rhodopsin kinase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

The origin and evolution of G protein-coupled receptor kinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Clinical trial design for adenoviral gene therapy products.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Binding potency of paroxetine analogues for the 5-hydroxytryptamine uptake complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Kinetic analysis of protein kinase C inhibition by staurosporine: evidence that inhibition entails inhibitor binding at a conserved region of the catalytic domain but not competition with substrates

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Inhibition of [3H]paroxetine binding by various serotonin uptake inhibitors: structure-activity relationships

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Processing of X-ray diffraction data collected in oscillation mode

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3913355

Binding potency of 6-nitroquipazine analogues for the 5-hydroxytryptamine reuptake complex

27 November 2018

1 reference

12 December 2020

Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation

1 reference

12 December 2020

In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function

1 reference

12 December 2020

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart

1 reference

12 December 2020

8 Preparation of retinal rod outer segments

1 reference

12 December 2020

Identifiers

DOI

10.1124/MOL.113.089631

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24220010%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

2 references

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6 June 2020

PubMed publication ID

24220010

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24220010%20AND%20SRC:MED&resulttype=core&format=json