K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions (Q27680654)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Jonathan M Ostrem

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Martin L Sos

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

James A Wells

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Kevan M Shokat

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

language of work or name

English

0 references

publication date

20 November 2013

1 reference

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1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

503

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

7477

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

548-551

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

1 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Turning a protein kinase on or off from a single allosteric site via disulfide trapping

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

The Catalogue of Somatic Mutations in Cancer (COSMIC)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Site-directed ligand discovery

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Guanosine triphosphatase stimulation of oncogenic Ras mutants

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Simple one-pot synthesis of disulfide fragments for use in disulfide-exchange screening

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

29 September 2017

A Ras by any other name

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

The differential effects of the Gly-60 to Ala mutation on the interaction of H-Ras p21 with different downstream targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274051

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE12796

Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE12796

K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24256730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24256730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE12796

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 March 2020

1025089044

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24256730%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2 references