Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6 (Q27682291)

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Matthew Ling-Hon Chu

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Michael D Enos

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Niket Shah

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

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language of work or name

English

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publication date

18 March 2014

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published in

eLife

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volume

3

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page(s)

e01998

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cites work

1 reference

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Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

20 March 2017

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

20 March 2017

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Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

20 March 2017

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Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors

20 March 2017

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Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

20 March 2017

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Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

20 March 2017

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The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation

20 March 2017

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Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

20 March 2017

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Structure of GSK3beta reveals a primed phosphorylation mechanism

20 March 2017

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The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

20 March 2017

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The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

20 March 2017

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A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

20 March 2017

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

20 March 2017

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Glycogen synthase kinase-3: properties, functions, and regulation

20 March 2017

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20 March 2017

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

20 March 2017

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20 March 2017

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How good are my data and what is the resolution?

20 March 2017

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

7 April 2017

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The glamour and gloom of glycogen synthase kinase-3

7 April 2017

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7 April 2017

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Development of Akt-activated GSK3β inhibitory peptide

7 April 2017

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Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling

29 September 2017

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GSK-3: Functional Insights from Cell Biology and Animal Models

29 September 2017

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29 September 2017

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What Are the bona fide GSK3 Substrates?

29 September 2017

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29 September 2017

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Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

29 September 2017

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Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

29 September 2017

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Regulation of Lrp6 phosphorylation

29 September 2017

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Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

29 September 2017

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G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

29 September 2017

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Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.

29 September 2017

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GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics

29 September 2017

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Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs

29 September 2017

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Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action

29 September 2017

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Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic.

29 September 2017

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Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

29 September 2017

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Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines

29 September 2017

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A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

29 September 2017

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GSK3 takes centre stage more than 20 years after its discovery

29 September 2017

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

29 September 2017

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29 September 2017

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29 September 2017

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Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate

2 June 2018

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21 January 2018

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Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

21 January 2018

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