Sulindac-Derived RXRα Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site (Q27682952)

2

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Alexander E Aleshin

3

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Fan Chen

4

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Jiebo Chen

5

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Fuquan Jiang

6

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Gulimiran Alitongbieke

7

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Zhiping Zeng

8

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Yue Ma

9

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Mingfeng Huang

10

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Hu Zhou

11

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Gregory Cadwell

12

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Jian-Feng Zheng

13

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Pei-Qiang Huang

14

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Robert C Liddington

15

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Xiao-kun Zhang

16

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Ying Su

The “Phantom Effect” of the Rexinoid LG100754: Structural and Functional Insights

17

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publication date

22 May 2014

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published in

Chemistry and Biology

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volume

21

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page(s)

596-607

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issue

5

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cites work

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The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain

29 September 2017

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Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.

29 September 2017

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Tumor necrosis factor and cancer, buddies or foes?

29 September 2017

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Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor

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29 September 2017

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Design of selective nuclear receptor modulators: RAR and RXR as a case study

29 September 2017

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A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta

29 September 2017

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Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260.

29 September 2017

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A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced prostate cancer

29 September 2017

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The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis

29 September 2017

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Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting

29 September 2017

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Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling

29 September 2017

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5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods

29 September 2017

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Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid

29 September 2017

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Changes in expression and subcellular localization of nuclear retinoic acid receptors in human endometrial epithelium during the menstrual cycle

29 September 2017

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Role of BAX in the apoptotic response to anticancer agents

29 September 2017

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Clinical pharmacokinetics of sulindac. A dynamic old drug

29 September 2017

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Retinoid X receptor alpha forms tetramers in solution

29 September 2017

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"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer

29 September 2017

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Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

2 June 2018

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Endocrine regulation of mitochondrial activity: involvement of truncated RXRalpha and c-Erb Aalpha1 proteins

2 June 2018

1 reference

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Kinetics of the tissue distributions of sulindac and metabolites. Relevance to sites and rates of bioactivation.

2 June 2018

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Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

2 June 2018

1 reference

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LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators

2 June 2018

1 reference

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The bioisosteric similarity of the tetrazole and carboxylate anions: clues from the topologies of the electrostatic potential and of the electron density

27 November 2018

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Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding

27 November 2018

1 reference

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

27 November 2018

1 reference

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Purification, Functional Characterization, and Crystallization of the Ligand Binding Domain of the Retinoid X Receptor

27 November 2018

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12 December 2020

Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR

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12 December 2020

Tumour necrosis factor and cancer

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12 December 2020

Ligand- and DNA-induced dissociation of RXR tetramers 1 1Edited by M. Yaniv

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Auto-silencing by the retinoid X receptor 1 1Edited by M. Yaniv

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12 December 2020

Cellular and subcellular localization of six retinoid receptors in rat testis during postnatal development: identification of potential heterodimeric receptors

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12 December 2020