Design of selective nuclear receptor modulators: RAR and RXR as a case study (Q36956235)

17 August 2017

1 reference

title

Design of selective nuclear receptor modulators: RAR and RXR as a case study (English)

1 reference

17 August 2017

1 reference

ChEBI release 2020-05-28

William Bourguet

2

0 references

Hinrich Gronemeyer

object named as

Hinrich Gronemeyer

series ordinal

4

0 references

Lucia Altucci

object named as

Lucia Altucci

series ordinal

3

0 references

Angel R de Lera

object named as

Angel R de Lera

series ordinal

1

0 references

publication date

1 October 2007

1 reference

Nature Reviews Drug Discovery

17 August 2017

1 reference

17 August 2017

6

1 reference

17 August 2017

10

1 reference

17 August 2017

811-820

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd2398

17 August 2017

0 references

cites work

Principles for modulation of the nuclear receptor superfamily

1 reference

Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis

31 March 2020

1 reference

In vivo activation of PPAR target genes by RXR homodimers

31 March 2020

1 reference

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

31 March 2020

1 reference

Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.

31 March 2020

1 reference

Selective retinoids and rexinoids in cancer therapy and chemoprevention

31 March 2020

1 reference

Synthetic retinoids and their nuclear receptors

31 March 2020

1 reference

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

31 March 2020

1 reference

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

31 March 2020

1 reference

Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

31 March 2020

1 reference

A canonical structure for the ligand-binding domain of nuclear receptors

31 March 2020

1 reference

Nuclear receptor coregulators: multiple modes of modification

31 March 2020

1 reference

Coregulator function: a key to understanding tissue specificity of selective receptor modulators

31 March 2020

1 reference

Transcriptional regulation by steroid receptor coactivator phosphorylation

31 March 2020

1 reference

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

31 March 2020

1 reference

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

31 March 2020

1 reference

Separation of retinoid X receptor homo- and heterodimerization functions

31 March 2020

1 reference

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

31 March 2020

1 reference

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

31 March 2020

1 reference

Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level

31 March 2020

1 reference

Structural determinants of allosteric ligand activation in RXR heterodimers.

31 March 2020

1 reference

Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors

31 March 2020

1 reference

Nuclear hormone receptors and gene expression

31 March 2020

1 reference

Combinatorial control of gene expression by nuclear receptors and coregulators

31 March 2020

1 reference

Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions

31 March 2020

1 reference

Rational design of RAR-selective ligands revealed by RARbeta crystal structure

31 March 2020

1 reference

Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists

31 March 2020

1 reference

Conformational adaptation of agonists to the human nuclear receptor RAR gamma

31 March 2020

1 reference

Activation of mammalian retinoid X receptors by the insect growth regulator methoprene

31 March 2020

1 reference

Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR

31 March 2020

1 reference

Phytanic acid is a retinoid X receptor ligand

31 March 2020

1 reference

Molecular recognition of agonist ligands by RXRs

31 March 2020

1 reference

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

31 March 2020

1 reference

Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma

31 March 2020

1 reference

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

31 March 2020

1 reference

Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3

31 March 2020

1 reference

Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha

31 March 2020

1 reference

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation

31 March 2020

1 reference

Dynamic stabilization of nuclear receptor ligand binding domains by hormone or corepressor binding

31 March 2020

1 reference

Molecular sensors of estrogen receptor conformations and dynamics

31 March 2020

1 reference

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.

31 March 2020

1 reference

Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation

31 March 2020

1 reference

Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids

31 March 2020

1 reference

Synthesis of novel retinoid X receptor-selective retinoids.

31 March 2020

1 reference

Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

31 March 2020

1 reference

Synthesis and biological activity of retinoic acid receptor-alpha specific amides

31 March 2020

1 reference

Identification of highly potent retinoic acid receptor alpha-selective antagonists

31 March 2020

1 reference

Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes

31 March 2020

1 reference

Structural basis for isotype selectivity of the human retinoic acid nuclear receptor

31 March 2020

1 reference

Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma

31 March 2020

1 reference

Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes

31 March 2020

1 reference

Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells

31 March 2020

1 reference

4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists

31 March 2020

1 reference

Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2398

1 reference

PubMed ID

17906643

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17906643