A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site (Q27694705)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

title

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

author name string

Mary Ann Hardwicke

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Alan R Rendina

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Michael L Moore

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Liping Wang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Julie A Krueger

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Ramona N Plant

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Rachel D Totoritis

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Guofeng Zhang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Jacques Briand

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

William A Burkhart

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Kristin K Brown

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Cynthia A Parrish

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

publication date

3 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

page(s)

774-779

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

Structure and molecular organization of mammalian fatty acid synthase

11 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Structure of fungal fatty acid synthase and implications for iterative substrate shuttling

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Fatty acid synthesis: a potential selective target for antineoplastic therapy

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

The crystal structure of a mammalian fatty acid synthase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Regulation of cancer cell metabolism

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Phasercrystallographic software

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Overview of the CCP4 suite and current developments

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Features and development of Coot

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1603

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Structure and function of animal fatty acid synthase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Mitochondrial fatty acid synthesis type II: more than just fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Two-site ELISA for the quantitative determination of fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Fatty acid synthase as a potential therapeutic target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Fatty acid synthase and cancer: new application of an old pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

New synthetic inhibitors of fatty acid synthase with anticancer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Substrate recognition by the human fatty-acid synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Simultaneous quantification of malonyl-CoA and several other short-chain acyl-CoAs in animal tissues by ion-pairing reversed-phase HPLC/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Macromolecular TLS refinement in REFMAC at moderate resolutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1603

Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase

21 January 2018

1 reference

12 December 2020

Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure

1 reference

12 December 2020

Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells

1 reference

12 December 2020

Selective inhibition of fatty acid synthase for lung cancer treatment

1 reference

12 December 2020

Acetoacetyl-CoA reductase activity of lactating bovine mammary fatty acid synthase

1 reference

12 December 2020

Fatty acid synthetase from pig liver. 2. Characterization of the enzyme complex with oxidoreductase activity for alicyclic ketones as a fatty acid synthetase

1 reference

12 December 2020

STUDIES ON LIVER ALCOHOL HYDROGENASE COMPLEXES. 3. MULTIPLE INHIBITION KINETICS IN THE PRESENCE OF TWO COMPETITIVE INHIBITORS

1 reference

12 December 2020

Derivation of rate equations for multisite ping-pong mechanisms with ping-pong reactions at one or more sites.

1 reference

12 December 2020

Stereochemistry of the reactions catalyzed by chicken liver fatty acid synthase

1 reference

12 December 2020

Architecture of mammalian fatty acid synthase at 4.5 A resolution

1 reference

12 December 2020

Fatty acid synthetase. A steady state kinetic analysis of the reaction catalyzed by the enzyme from pigeon liver

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1603

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25086508%20AND%20SRC:MED&resulttype=core&format=json