Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis (Q29615683)

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7 January 2020

review article

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title

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis (English)

2 references

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30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17882277%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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7 January 2020

author name string

Ruth Lupu

series ordinal

2

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language of work or name

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30 April 2017

publication date

1 October 2007

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7 January 2020

published in

Nature Reviews Cancer

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7 January 2020

volume

7

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7 January 2020

page(s)

763-777

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7 January 2020

issue

10

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On the Origin of Cancer Cells

7 January 2020

cites work

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Energy boost: the Warburg effect returns in a new theory of cancer

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Glucose metabolism and cancer

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Energy deregulation: licensing tumors to grow

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Targets and mechanisms for the regulation of translation in malignant transformation

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When translation meets transformation: the mTOR story

31 March 2020

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Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme

31 March 2020

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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

31 March 2020

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Structure and function of animal fatty acid synthase

31 March 2020

1 reference

Structure and molecular organization of mammalian fatty acid synthase

31 March 2020

1 reference

Architecture of mammalian fatty acid synthase at 4.5 A resolution

31 March 2020

1 reference

Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase

31 March 2020

1 reference

Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells

31 March 2020

1 reference

Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium

31 March 2020

1 reference

Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!

31 March 2020

1 reference

Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast

31 March 2020

1 reference

31 March 2020

1 reference

Fatty acid synthesis: a potential selective target for antineoplastic therapy

31 March 2020

1 reference

Increased lipogenesis in cancer cells: new players, novel targets.

31 March 2020

1 reference

Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.

31 March 2020

1 reference

Fatty acid synthase and cancer: new application of an old pathway

31 March 2020

1 reference

Tumor cell metabolism: the marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution!

31 March 2020

1 reference

'Why do tumour cells glycolyse?': from glycolysis through citrate to lipogenesis

31 March 2020

1 reference

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

31 March 2020

1 reference

ATP citrate lyase is an important component of cell growth and transformation

31 March 2020

1 reference

ATP citrate lyase inhibition can suppress tumor cell growth

31 March 2020

1 reference

Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

31 March 2020

1 reference

RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells

31 March 2020

1 reference

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

31 March 2020

1 reference

Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility

31 March 2020

1 reference

Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition

31 March 2020

1 reference

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

31 March 2020

1 reference

The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer.

31 March 2020

1 reference

Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

31 March 2020

1 reference

Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival

31 March 2020

1 reference

Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas

31 March 2020

1 reference

Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma.

31 March 2020

1 reference

FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis

31 March 2020

1 reference

The 17q23 amplicon and breast cancer

31 March 2020

1 reference

Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma☆

31 March 2020

1 reference

Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of fatty acid synthase in rat liver

31 March 2020

1 reference

Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription

31 March 2020

1 reference

Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats

31 March 2020

1 reference

Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

31 March 2020

1 reference

Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism

31 March 2020

1 reference

Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.

31 March 2020

1 reference

Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer

31 March 2020

1 reference

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.

31 March 2020

1 reference

Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase

31 March 2020

1 reference

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

31 March 2020

1 reference

Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?

31 March 2020

1 reference

The SREBP pathway--insights from Insigs and insects

31 March 2020

1 reference

SREBP transcription factors: master regulators of lipid homeostasis

31 March 2020

1 reference

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

31 March 2020

1 reference

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

31 March 2020

1 reference

Mechanisms of nutritional and hormonal regulation of lipogenesis

31 March 2020

1 reference

Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins

31 March 2020

1 reference

Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c

31 March 2020

1 reference

Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence

31 March 2020

1 reference

In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells

31 March 2020

1 reference

Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway

31 March 2020

1 reference

Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?

31 March 2020

1 reference

Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia

31 March 2020

1 reference

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

31 March 2020

1 reference

The isopeptidase USP2a protects human prostate cancer from apoptosis

31 March 2020

1 reference

Selective activation of the fatty acid synthesis pathway in human prostate cancer

31 March 2020

1 reference

Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.

31 March 2020

1 reference

Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis

31 March 2020

1 reference

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity

31 March 2020

1 reference

Key role of mitochondria in cerulenin-mediated apoptosis

31 March 2020

1 reference

Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells

31 March 2020

1 reference

Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

31 March 2020

1 reference

Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells

31 March 2020

1 reference

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

31 March 2020

1 reference

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

31 March 2020

1 reference

Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

31 March 2020

1 reference

Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells

31 March 2020

1 reference

Fatty acid synthase: a novel target for antiglioma therapy

31 March 2020

1 reference

Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

31 March 2020

1 reference

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

31 March 2020

1 reference

Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer

31 March 2020

1 reference

Why do cancers have high aerobic glycolysis?

31 March 2020

1 reference

Hypoxia and adaptive landscapes in the evolution of carcinogenesis

31 March 2020

1 reference

Glycolysis in cancer: a potential target for therapy.

31 March 2020

1 reference

Going malignant: the hypoxia-cancer connection in the prostate

31 March 2020

1 reference

Fatty acid synthase: a metabolic oncogene in prostate cancer?

31 March 2020

1 reference

Akt stimulates aerobic glycolysis in cancer cells

31 March 2020

1 reference

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

31 March 2020

1 reference

Acid-mediated tumor invasion: a multidisciplinary study

31 March 2020

1 reference

Metabolic changes during carcinogenesis: potential impact on invasiveness.

31 March 2020

1 reference

Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue.

31 March 2020

1 reference

Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.

31 March 2020

1 reference

HIF-1 and tumor progression: pathophysiology and therapeutics

31 March 2020

1 reference

Targeting HIF-1 for cancer therapy

31 March 2020

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

31 March 2020

1 reference

Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha.

31 March 2020

1 reference

Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related

31 March 2020

1 reference

Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model

31 March 2020

1 reference

Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity

31 March 2020

1 reference

Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere).

31 March 2020

1 reference

Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer

31 March 2020

1 reference

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

31 March 2020

1 reference

"Spot 14" protein: a metabolic integrator in normal and neoplastic cells

31 March 2020

1 reference

The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism

31 March 2020

1 reference

Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker

31 March 2020

1 reference

Spot 14: A marker of aggressive breast cancer and a potential therapeutic target

31 March 2020

1 reference

BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains

31 March 2020

1 reference

BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase

31 March 2020

1 reference

BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.

31 March 2020

1 reference

Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

31 March 2020

1 reference

AMP-activated protein kinase signaling in metabolic regulation

31 March 2020

1 reference

AMPK, the metabolic syndrome and cancer

31 March 2020

1 reference

Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype

31 March 2020

1 reference

Evidence for a putative relationship between type 2 diabetes and neoplasia with particular reference to breast cancer: role of hormones, growth factors and specific receptors

31 March 2020

1 reference

The impact of body mass index and type 2 diabetes on breast cancer: current therapeutic measures of prevention

31 March 2020

1 reference

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

31 March 2020

1 reference

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

31 March 2020

1 reference

Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer

31 March 2020

1 reference

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

31 March 2020

1 reference

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

31 March 2020

1 reference

Autophagy is activated for cell survival after endoplasmic reticulum stress

31 March 2020

1 reference

Endoplasmic reticulum stress: a new pathway to induce autophagy.

31 March 2020

1 reference

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

31 March 2020

1 reference

Role of autophagy in cancer: management of metabolic stress

31 March 2020

1 reference

Metabolic catastrophe as a means to cancer cell death

31 March 2020

1 reference

31 March 2020

1 reference

Functional rafts in cell membranes

31 March 2020

1 reference

Lipids as targeting signals: lipid rafts and intracellular trafficking.

31 March 2020

1 reference

Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2.

31 March 2020

1 reference

Untangling the ErbB signalling network

31 March 2020

1 reference

Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer

31 March 2020

1 reference

The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

31 March 2020

1 reference

Update on HER-2 as a target for cancer therapy: the ERBB2 promoter and its exploitation for cancer treatment

31 March 2020

1 reference

A genomic explanation connecting "Mediterranean diet", olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (

31 March 2020

1 reference

EGF-ERBB signalling: towards the systems level

31 March 2020

1 reference

Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors.

31 March 2020

1 reference

C75 inhibits food intake by increasing CNS glucose metabolism

31 March 2020

1 reference

Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase

31 March 2020

1 reference

Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.

31 March 2020

1 reference

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31 March 2020

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

7 January 2020

1024304300

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350560

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17882277

3 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

350560

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17882277%20AND%20SRC:MED&resulttype=core&format=json