Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. (Q27704725)

20 June 2017

title

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. (English)

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20 June 2017

10

Paul Workman

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20 June 2017

Matthew D Cheeseman

1

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Alan M Jones

object named as

Alan M Jones

6

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author name string

Isaac M Westwood

2

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20 June 2017

Olivier Barbeau

3

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20 June 2017

Martin Rowlands

4

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20 June 2017

Sarah Dobson

5

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20 June 2017

Fiona Jeganathan

7

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20 June 2017

Rosemary Burke

8

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20 June 2017

Nadia Kadi

9

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20 June 2017

Ian Collins

11

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20 June 2017

Rob L M van Montfort

12

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20 June 2017

Keith Jones

13

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20 June 2017

language of work or name

English

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publication date

27 April 2016

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Journal of Medicinal Chemistry

20 June 2017

published in

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20 June 2017

volume

59

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20 June 2017

issue

10

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20 June 2017

page(s)

4625-4636

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Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

20 June 2017

cites work

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7 April 2017

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Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

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Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Error bars in experimental biology

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Chemical manipulation of hsp70 ATPase activity regulates tau stability.

2 June 2018

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Kinetics of nucleotide-induced changes in the tryptophan fluorescence of the molecular chaperone Hsc70 and its subfragments suggest the ATP-induced conformational change follows initial ATP binding

2 June 2018

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Recent progress in understanding activity cliffs and their utility in medicinal chemistry.

2 June 2018

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Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells.

27 November 2018

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Kinetic efficiency: the missing metric for enhancing compound quality?

27 November 2018

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ATPases as drug targets: insights from heat shock proteins 70 and 90.

27 November 2018

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Amide hydrogen exchange reveals conformational changes in hsp70 chaperones important for allosteric regulation.

27 November 2018

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Allosteric regulation of Hsp70 chaperones by a proline switch

27 November 2018

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An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines

27 November 2018

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Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor.

27 November 2018

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Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis

27 November 2018

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27 November 2018

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12 December 2020

Intramolecular hydrogen bonding in medicinal chemistry

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Relationship between intramolecular hydrogen bonding and solvent accessibility of side‐chain donors and acceptors in proteins

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SYNTHESIS OF PYRROLO(2,3-D)PYRIMIDINES. THE AGLYCONE OF TOYOCAMYCIN

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12 December 2020

10.1021/ACS.JMEDCHEM.5B02001

Identifiers

DOI

1 reference

OpenCitations bibliographic resource ID

20 June 2017

3118673

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3118673

PMC publication ID

5371393

0 references

1 reference