The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF (Q27853045)

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The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF

Language	Label	Description	Also known as
English	The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF	scientific article	The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF

Statements

scholarly article

1 reference

13 November 2016

The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF (English)

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13 November 2016

1 reference

based on heuristic

inferred from title

14

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Gordon B. Mills

13

object named as

Gordon B Mills

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author name string

Ian R Watson

1

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Liren Li

2

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Peter K Cabeceiras

3

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Mozhdeh Mahdavi

4

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Tony Gutschner

5

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Giannicola Genovese

6

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Guocan Wang

7

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Zhuangna Fang

8

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James M Tepper

9

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Katherine Stemke-Hale

10

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Kenneth Y Tsai

11

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Michael A Davies

12

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language of work or name

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publication date

1 September 2014

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Cancer Research

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74

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17

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4845-52

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A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition

1 reference

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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

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RAC1P29S is a spontaneously activating cancer-associated GTPase

1 reference

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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

1 reference

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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

1 reference

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Melanoma: from mutations to medicine

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

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MEK1 mutations confer resistance to MEK and B-RAF inhibition

1 reference

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Rho GTPases: biochemistry and biology

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Mutations of the BRAF gene in human cancer

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

1 reference

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Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

1 reference

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

1 reference

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Emerging insights into resistance to BRAF inhibitors in melanoma

1 reference

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Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

1 reference

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MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition

1 reference

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The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

1 reference

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A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

1 reference

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C-RAF mutations confer resistance to RAF inhibitors

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Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors

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PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

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Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

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29 September 2017

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