Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil (Q27863401)

PubMed publication ID

19402749

15 November 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19402749%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil (English)

2 references

PubMed publication ID

19402749

15 November 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19402749%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

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1 reference

1

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27 January 2020

Jim Selfridge

6

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27 January 2020

Primo Schär

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27 January 2020

author name string

Frauke Focke

2

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27 January 2020

Yusuke Saito

3

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27 January 2020

David Schuermann

4

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27 January 2020

Teresa Lettieri

5

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27 January 2020

language of work or name

English

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publication date

1 April 2009

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27 January 2020

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27 January 2020

volume

7

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27 January 2020

issue

4

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27 January 2020

page(s)

e91

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Creative Commons Attribution 4.0 International

27 January 2020

copyright license

start time

28 April 2009

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April 2022 Public Data File from Crossref

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copyrighted

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ImageQuant TL

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

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hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

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Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

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5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems

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Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer

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The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.

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Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines

2 June 2018

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Proteolytic degradation of the nuclear isoform of uracil-DNA glycosylase occurs during the S phase of the cell cycle

27 November 2018

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Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition

27 November 2018

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Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

27 November 2018

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Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis

27 November 2018

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27 November 2018

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Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed

27 November 2018

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12 December 2020

Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine

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12 December 2020

Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells

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12 December 2020

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency

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12 December 2020

Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase

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12 December 2020

10.1371/JOURNAL.PBIO.1000091

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19402749%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19402749%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

19402749

2 references