Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum (Q27939524)

Alpha-1,2-mannosidase MNL1 YHR204W

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Yos9p YDR057W

1 reference

GOA release 2020-03-11

author

Markus Aebi

7

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author name string

Simone Clerc

0 references

Christian Hirsch

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Daniela Maria Oggier

3

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Paola Deprez

4

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Claude Jakob

5

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Thomas Sommer

Defining the glycan destruction signal for endoplasmic reticulum-associated degradation

6

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language of work or name

English

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publication date

12 January 2009

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published in

Journal of Cell Biology

1 reference

1 December 2016

184

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cites work

1 reference

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

20 March 2017

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A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

20 March 2017

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The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

20 March 2017

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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

20 March 2017

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Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.

20 March 2017

1 reference

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Yos9p detects and targets misfolded glycoproteins for ER-associated degradation

20 March 2017

1 reference

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Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen

20 March 2017

1 reference

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Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

20 March 2017

1 reference

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Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue

20 March 2017

1 reference

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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

20 March 2017

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Free-oligosaccharide control in the yeast Saccharomyces cerevisiae: roles for peptide:N-glycanase (Png1p) and vacuolar mannosidase (Ams1p)

20 March 2017

1 reference

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Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

20 March 2017

1 reference

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Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast

20 March 2017

1 reference

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A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

20 March 2017

1 reference

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Probability-based protein identification by searching sequence databases using mass spectrometry data

20 March 2017

1 reference

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Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Role of Cue1p in ubiquitination and degradation at the ER surface

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast

20 March 2017

1 reference

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STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo

20 March 2017

1 reference

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Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines

20 March 2017

1 reference

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Assembly of asparagine-linked oligosaccharides

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Roles of N-linked glycans in the endoplasmic reticulum

20 March 2017

1 reference

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Guide to yeast genetics and molecular biology

7 April 2017

1 reference

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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae

7 April 2017

1 reference

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The EDEM and Yos9p families of lectin-like ERAD factors

7 April 2017

1 reference

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N-glycan structure dictates extension of protein folding or onset of disposal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

N-linked glycan recognition and processing: the molecular basis of endoplasmic reticulum quality control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Free N-linked oligosaccharide chains: formation and degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6-5GlcNAc2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong alpha1-antitrypsin by human ER mannosidase I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

The unfolded protein response in a dolichyl phosphate mannose-deficient Chinese hamster ovary cell line points out the key role of a demannosylation step in the quality-control mechanism of N-glycoproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

N-glycan structure of a short-lived variant of ribophorin I expressed in the MadIA214 glycosylation-defective cell line reveals the role of a mannosidase that is not ER mannosidase I in the process of glycoprotein degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Calcium binding to the class I alpha-1,2-mannosidase from Saccharomyces cerevisiae occurs outside the EF hand motif

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

The dolichol pathway of N-linked glycosylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Intracellular disposal of incompletely folded human alpha1-antitrypsin involves release from calnexin and post-translational trimming of asparagine-linked oligosaccharides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Glycosidases of the asparagine-linked oligosaccharide processing pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Proteinase C (carboxypeptidase Y) mutant of yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Processing of N-linked glycans during endoplasmic-reticulum-associated degradation of a short-lived variant of ribophorin I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Molecular cloning and enzymatic characterization of a Trichoderma reesei 1,2-alpha-D-mannosidase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

Pre-Golgi degradation of yeast prepro-alpha-factor expressed in a mammalian cell. Influence of cell type-specific oligosaccharide processing on intracellular fate

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615083

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.200809198

DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.200809198

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.200809198

Genetic tailoring of N-linked oligosaccharides: the role of glucose residues in glycoprotein processing of Saccharomyces cerevisiae in vivo

21 January 2018

1 reference

12 December 2020

Importance of carbohydrate positioning in the recognition of mutated CPY for ER-associated degradation

1 reference

12 December 2020

Glycoprotein synthesis in yeast. Identification of Man8GlcNAc2 as an essential intermediate in oligosaccharide processing

1 reference

12 December 2020

A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum

1 reference

12 December 2020

Effect of cell attachment and growth on the synthesis and fate of dolichol-linked oligosaccharides in Chinese hamster ovary cells

1 reference

12 December 2020

Purification to homogeneity of UDP-glucose:glycoprotein glucosyltransferase from Schizosaccharomyces pombe and apparent absence of the enzyme fro Saccharomyces cerevisiae

1 reference

12 December 2020

Calnexin, calreticulin and the folding of glycoproteins

1 reference

12 December 2020

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200809198

1 reference

3862815

3862815

1 reference

1 reference

1 reference