Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures (Q27990101)

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29 February 2020

title

Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures (English)

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29 February 2020

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4

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29 February 2020

Penny Nymark

2

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29 February 2020

Egon Willighagen

6

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29 February 2020

8

Samuel Kaski

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29 February 2020

author name string

Vesa Hongisto

3

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29 February 2020

Roland C Grafström

1

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29 February 2020

Rebecca Ceder

5

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29 February 2020

Barry Hardy

7

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29 February 2020

Pekka Kohonen

9

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29 February 2020

language of work or name

English

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publication date

1 November 2015

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Alternatives to Laboratory Animals

29 February 2020

number of pages

8

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published in

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29 February 2020

volume

43

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29 February 2020

issue

5

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29 February 2020

page(s)

325-332

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Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

29 February 2020

cites work

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Developing tools for defining and establishing pathways of toxicity

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The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing

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The Connectivity Map: a new tool for biomedical research

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Toxicokinetic Triage for Environmental Chemicals

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Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

1 January 2022

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Cancer Biology, Toxicology and Alternative Methods Development Go Hand-in-Hand

1 January 2022

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SEURAT: Safety Evaluation Ultimately Replacing Animal Testing--recommendations for future research in the field of predictive toxicology

1 January 2022

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A framework for the next generation of risk science

1 January 2022

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Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions

1 January 2022

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Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential

1 January 2022

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Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

1 January 2022

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Adverse outcome pathway development II: best practices.

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A decade of toxicogenomic research and its contribution to toxicological science

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Application of connectivity mapping in predictive toxicology based on gene-expression similarity.

1 January 2022

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Consensus report on the future of animal-free systemic toxicity testing

1 January 2022

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Probabilistic drug connectivity mapping

1 January 2022

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The Comparative Toxicogenomics Database's 10th year anniversary: update 2015.

1 January 2022

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Quantitative in vitro-to-in vivo extrapolation in a high-throughput environment

1 January 2022

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Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action

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The evolution of bioinformatics in toxicology: advancing toxicogenomics

1 January 2022

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Cellular stress response pathway system as a sentinel ensemble in toxicological screening

1 January 2022

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Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage

1 January 2022

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Big data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicants

1 January 2022

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Adverse outcome pathway (AOP) development I: strategies and principles

1 January 2022

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Open TG-GATEs: a large-scale toxicogenomics database

1 January 2022

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FutureTox II: in vitro data and in silico models for predictive toxicology

1 January 2022

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LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

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Risk assessment in the 21st century: roadmap and matrix.

1 January 2022

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Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment

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Toward predictive models for drug-induced liver injury in humans: are we there yet?

1 January 2022

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Experiences with workflows for automating data-intensive bioinformatics

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Lean Big Data integration in systems biology and systems pharmacology

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Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer

1 January 2022

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A community effort to assess and improve drug sensitivity prediction algorithms.

1 January 2022

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The liver pharmacological and xenobiotic gene response repertoire

1 January 2022

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The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals.

1 January 2022

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5 May 2024

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Identifiers

DOI

10.1177/026119291504300506

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26551289%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

29 February 2020

4790337

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4790337

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4790337