Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance? (Q28069021)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

review article

2 references

16 July 2021

Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance? (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

28 September 2019

deubiquitinating enzymes

1 reference

16 July 2021

Gloria López-Castejón

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Mariola J. Ferraro

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

author name string

Mariola J. Edelmann

series ordinal

2

1 reference

language of work or name

1 reference

14 August 2016

3 references

28 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

16 July 2021

Mediators of Inflammation

4 references

28 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

16 July 2021

2016

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

page(s)

3481371

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

22 March 2020

copyright license

2 references

28 September 2019

Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling

16 July 2021

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

20 March 2017

1 reference

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

20 March 2017

1 reference

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Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase

20 March 2017

1 reference

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Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation

20 March 2017

1 reference

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FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

20 March 2017

1 reference

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CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha

20 March 2017

1 reference

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Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

20 March 2017

1 reference

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

20 March 2017

1 reference

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HAUSP/USP7 as an Epstein-Barr virus target

20 March 2017

1 reference

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OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

ChlaDub1 of Chlamydia trachomatis suppresses NF-kappaB activation and inhibits IkappaBalpha ubiquitination and degradation

20 March 2017

1 reference

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The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection

20 March 2017

1 reference

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Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation

20 March 2017

1 reference

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Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation

20 March 2017

1 reference

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Deubiquitinases (DUBs) and DUB inhibitors: a patent review

20 March 2017

1 reference

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Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Activation and regulation of the inflammasomes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

7 April 2017

1 reference

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Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors

7 April 2017

1 reference

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Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7.

29 September 2017

1 reference

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LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

29 September 2017

1 reference

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Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.

29 September 2017

1 reference

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The critical role of toll-like receptors--From microbial recognition to autoimmunity: A comprehensive review.

29 September 2017

1 reference

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USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms

29 September 2017

1 reference

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Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.

29 September 2017

1 reference

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Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase

29 September 2017

1 reference

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Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation

29 September 2017

1 reference

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DUBs, the regulation of cell identity and disease

29 September 2017

1 reference

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A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity

29 September 2017

1 reference

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The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation

29 September 2017

1 reference

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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

29 September 2017

1 reference

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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

29 September 2017

1 reference

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The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

29 September 2017

1 reference

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Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway

29 September 2017

1 reference

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HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination

29 September 2017

1 reference

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USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

29 September 2017

1 reference

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Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

29 September 2017

1 reference

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Smac mimetics and innate immune stimuli synergize to promote tumor death

29 September 2017

1 reference

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USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

29 September 2017

1 reference

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Regulation of proteolysis by human deubiquitinating enzymes

29 September 2017

1 reference

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USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex

29 September 2017

1 reference

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Molecular mechanisms and functions of cytokine-inducible deubiquitinating enzymes

29 September 2017

1 reference

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Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells.

29 September 2017

1 reference

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The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

29 September 2017

1 reference

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Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.

29 September 2017

1 reference

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Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription

29 September 2017

1 reference

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Deubiquitinases as a signaling target of oxidative stress

29 September 2017

1 reference

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Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

29 September 2017

1 reference

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A20: linking a complex regulator of ubiquitylation to immunity and human disease

29 September 2017

1 reference

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Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation

29 September 2017

1 reference

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MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy

29 September 2017

1 reference

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Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications

29 September 2017

1 reference

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USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.

29 September 2017

1 reference

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Direct, noncatalytic mechanism of IKK inhibition by A20.

29 September 2017

1 reference

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PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications

29 September 2017

1 reference

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Targeting Toll-like receptors: emerging therapeutics?

29 September 2017

1 reference

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Signaling to NF-kappaB: regulation by ubiquitination

29 September 2017

1 reference

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Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

29 September 2017

1 reference

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Inactivation of HAUSP in vivo modulates p53 function

29 September 2017

1 reference

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Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

29 September 2017

1 reference

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

29 September 2017

1 reference

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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

29 September 2017

1 reference

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NOD-like receptors: role in innate immunity and inflammatory disease

29 September 2017

1 reference

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Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles

29 September 2017

1 reference

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Tumor suppressor CYLD: negative regulation of NF-kappaB signaling and more

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination

29 September 2017

1 reference

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Cooperation of Toll-like receptor signals in innate immune defence

29 September 2017

1 reference

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Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

29 September 2017

1 reference

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Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002299

Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.

2 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-beta1 and TGF-beta3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3481371

Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/27597804

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/27597804

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/27597804

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2016/3481371

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27597804%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PubMed publication ID

27597804

2 references