The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine (Q28070246)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26741401%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Abdirahman Abdi

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2

1 reference

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10 June 2020

author name string

PETER C. BULL

series ordinal

1

1 reference

ABDIRAHMAN I. ABDI

series ordinal

2

1 reference

language of work or name

1 reference

February 2016

1 reference

1 February 2016

8 references

23 March 2019

20 June 2019

30 June 2019

22 October 2019

21 December 2019

28 May 2020

18 July 2021

14 January 2024

10 references

23 March 2019

20 June 2019

30 June 2019

22 October 2019

21 December 2019

28 May 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26741401%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

18 July 2021

14 January 2024

143

2 references

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10 June 2020

issue

2

2 references

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10 June 2020

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171-186

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Creative Commons Attribution 4.0 International

10 June 2020

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on focus list of Wikimedia project

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cites work

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20 March 2017

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Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria

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Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

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29 September 2017

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Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

29 September 2017

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29 September 2017

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Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria

29 September 2017

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Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Plasmodium falciparum rosetting epitopes converge in the SD3-loop of PfEMP1-DBL1α.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children

29 September 2017

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29 September 2017

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Plasmodium falciparum var gene expression is modified by host immunity

29 September 2017

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Analysis of Plasmodium falciparum var genes expressed in children from Papua New Guinea

29 September 2017

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Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications.

29 September 2017

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Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).

29 September 2017

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29 September 2017

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Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African children

29 September 2017

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Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks

29 September 2017

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Barriers to antigenic escape by pathogens: trade-off between reproductive rate and antigenic mutability.

29 September 2017

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PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria

29 September 2017

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Population genomics of the immune evasion (var) genes of Plasmodium falciparum

29 September 2017

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Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates

29 September 2017

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Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria

29 September 2017

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Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration

29 September 2017

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Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domain

29 September 2017

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Limited cross-reactivity among domains of the Plasmodium falciparum clone 3D7 erythrocyte membrane protein 1 family

29 September 2017

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Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia

29 September 2017

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Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children

29 September 2017

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Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study

29 September 2017

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Immunoglobulin G isotype responses to erythrocyte surface-expressed variant antigens of Plasmodium falciparum predict protection from malaria in African children

29 September 2017

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Why do some African children develop severe malaria?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Virulence in malaria: an evolutionary viewpoint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Immunization with PfEMP1-DBL1alpha generates antibodies that disrupt rosettes and protect against the sequestration of Plasmodium falciparum-infected erythrocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

A review of hyperendemic malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Induction of crossreactive antibodies against the Plasmodium falciparum variant protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Recombinant Duffy binding-like-alpha domains of Plasmodium falciparum erythrocyte membrane protein 1 elicit antibodies in rats that recognise conserved epitopes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Low antibody responses to variant surface antigens of Plasmodium falciparum are associated with severe malaria and increased susceptibility to malaria attacks in Gabonese children.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: a parasite adhesion trait implicated in cerebral malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum-infected erythrocyte are encoded by the rif gene family and are the target of human immune responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

The role of variant surface antigens on malaria-infected red blood cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Virulence and transmission success of the malarial parasite Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Receptor-specific adhesion and clinical disease in Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Identification of a region of PfEMP1 that mediates adherence of Plasmodium falciparum infected erythrocytes to CD36: conserved function with variant sequence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Diversity and virulence thresholds in AIDS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Plasmodium falciparum rosetting is associated with malaria severity in Kenya

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Determinant spreading and the dynamics of the autoimmune T-cell repertoire.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Splenic requirement for antigenic variation and expression of the variant antigen on the erythrocyte membrane in cloned Plasmodium knowlesi malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Antigenic variation in Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Malaria--a neglected disease?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Antigenicity of the infected-erythrocyte and merozoite surfaces in Falciparum malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Sex: how malaria parasites get turned on.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Prognostic indicators of life-threatening malaria are associated with distinct parasite variant antigen profiles

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Diversity of agglutinating phenotype, cytoadherence, and rosette-forming characteristics of Plasmodium falciparum isolates from Papua New Guinean children.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Diversity of antigens expressed on the surface of erythrocytes infected with mature Plasmodium falciparum parasites in Papua New Guinea

2 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

2 June 2018

https://api.crossref.org/works/10.1017%2FS0031182015001274

inferred from DOI database lookup

7 January 2021

based on heuristic

Rapid switching to multiple antigenic and adhesive phenotypes in malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Agglutination of Plasmodium falciparum-infected erythrocytes from east and west African isolates by human sera from distant geographic regions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family.

2 June 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

MHC polymorphism and parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Protection against clinical malaria by heterologous immunoglobulin G antibodies against malaria-infected erythrocyte variant surface antigens requires interaction with asymptomatic infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

3D7-Derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Serological diversity of antigens expressed on the surface of erythrocytes infected with Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Acquired immunity and postnatal clinical protection in childhood cerebral malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Gradual acquisition of immunity to severe malaria with increasing exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Plasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

The NTS-DBL2X region of VAR2CSA induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Antibodies to variable Plasmodium falciparum-infected erythrocyte surface antigens are associated with protection from novel malaria infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Differentiating the pathologies of cerebral malaria by postmortem parasite counts

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Immunogen design for HIV-1 and influenza.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

The sound of sexual commitment breaks the silencing of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Immunization of Aotus monkeys with recombinant cysteine-rich interdomain region 1 alpha protects against severe disease during Plasmodium falciparum reinfection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182015001274

Plasmodium falciparum parasitaemia described by a new mathematical model.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825093

10.1017/S0031182015001274

27 November 2018

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26741401%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26741401%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

2 references