Anti-tumor activity of metformin: from metabolic and epigenetic perspectives (Q28080170)

Wuxiang Mao

2

1 reference

Yansheng Zhai

3

1 reference

Chong Tong

4

1 reference

Min Liu

5

1 reference

Lixin Ma

6

1 reference

Xiaolan Yu

7

1 reference

Shanshan Li

8

1 reference

language of work or name

1 reference

26 November 2016

1 reference

Creative Commons Attribution 3.0 Unported

PubMed

17 January 2017

6 references

3 April 2019

8 September 2019

7 November 2019

14 September 2020

25 September 2020

8 February 2021

7 references

3 April 2019

8 September 2019

7 November 2019

14 September 2020

25 September 2020

8 February 2021

6 references

3 April 2019

8 September 2019

7 November 2019

14 September 2020

25 September 2020

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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Metformin and reduced risk of cancer in diabetic patients

25 May 2017

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

25 May 2017

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TSC2 mediates cellular energy response to control cell growth and survival

25 May 2017

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Non-metabolic functions of glycolytic enzymes in tumorigenesis

25 May 2017

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Metformin potentiates anti-tumor effect of resveratrol on pancreatic cancer by down-regulation of VEGF-B signaling pathway

29 September 2017

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Metformin mediated reversal of epithelial to mesenchymal transition is triggered by epigenetic changes in E-cadherin promoter

29 September 2017

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Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours

29 September 2017

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Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

29 September 2017

1 reference

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Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription

29 September 2017

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Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway

29 September 2017

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Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro

29 September 2017

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VITAMIN B12 LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON METFORMIN.

29 September 2017

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Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence

29 September 2017

1 reference

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Vitamin B12 screening in metformin-treated diabetics in primary care: were elderly patients less likely to be tested?

29 September 2017

1 reference

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The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development

29 September 2017

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Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

29 September 2017

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p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

29 September 2017

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Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity

29 September 2017

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Immune-mediated antitumor effect by type 2 diabetes drug, metformin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

29 September 2017

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Host-virus interactions: from the perspectives of epigenetics

29 September 2017

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Resveratrol plays dual roles in pancreatic cancer cells

29 September 2017

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Metformin targets c-MYC oncogene to prevent prostate cancer.

29 September 2017

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New perspective for an old antidiabetic drug: metformin as anticancer agent.

29 September 2017

1 reference

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

29 September 2017

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Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line

29 September 2017

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Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

29 September 2017

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Dietary restriction (DR) and its advantages

29 September 2017

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In vitro and in vivo anti-melanoma action of metformin.

29 September 2017

1 reference

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

29 September 2017

1 reference

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Understanding the benefit of metformin use in cancer treatment

29 September 2017

1 reference

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Glucose metabolism induces mono-ubiquitination of histone H2B in mammalian cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Metformin: taking away the candy for cancer?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

29 September 2017

1 reference

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Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy

29 September 2017

1 reference

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Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Cross-talk between histone H3 tails produces cooperative nucleosome acetylation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Requirements for CD8 T-cell priming, memory generation and maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

29 September 2017

1 reference

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Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Metformin inhibits histone H2B monoubiquitination and downstream gene transcription in human breast cancer cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Metformin, B(12), and enhanced breast cancer response to chemotherapy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

The Gcn5 bromodomain of the SAGA complex facilitates cooperative and cross-tail acetylation of nucleosomes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354934