The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human (Q28081321)

Crossref

Xuezhi Dai

series ordinal

2

1 reference

Crossref

Jane H. Buckner

series ordinal

3

1 reference

Crossref

language of work or name

1 reference

1 April 2015

1 reference

published in

Journal of Immunology

1 reference

volume

194

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issue

7

1 reference

page(s)

2977-84

1 reference

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

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1 reference

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Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

20 March 2017

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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

20 March 2017

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Identification of substrates of human protein-tyrosine phosphatase PTPN22

20 March 2017

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Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

20 March 2017

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Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells

20 March 2017

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High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis

20 March 2017

1 reference

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

20 March 2017

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Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

20 March 2017

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A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

20 March 2017

1 reference

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

20 March 2017

1 reference

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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

20 March 2017

1 reference

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The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling

20 March 2017

1 reference

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PTPN22: the archetypal non-HLA autoimmunity gene

9 May 2017

1 reference

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Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

29 September 2017

1 reference

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PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells

29 September 2017

1 reference

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Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.

29 September 2017

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A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

29 September 2017

1 reference

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The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.

29 September 2017

1 reference

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PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.

29 September 2017

1 reference

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Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

29 September 2017

1 reference

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PTPN22 alters the development of regulatory T cells in the thymus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

LYP inhibits T-cell activation when dissociated from CSK.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

Adopting the good reFLEXes when generating conditional alterations in the mouse genome

29 September 2017

1 reference

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Requirement of PEST domain tyrosine phosphatase PEP in B cell antigen receptor-induced growth arrest and apoptosis

29 September 2017

1 reference

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Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase

29 September 2017

1 reference

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PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.

29 September 2017

1 reference

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Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.

27 November 2018

1 reference

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Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-γ-induced signaling in human monocytes

27 November 2018

1 reference

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Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369788

Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795788

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1403034

0 references

1 reference

PubMed publication ID

25795788

1 reference