BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping (Q28115349)

3 January 2017

title

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping (English)

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BRCA2 DNA repair associated

3 January 2017

main subject

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TERF2 interacting protein

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RAD51 recombinase

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RAD51 recombinase

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RAD51 paralog C

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Breast cancer 2, early onset

1 reference

Ana Rita Carlos

4

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Maria A Blasco

object named as

Maria A. Blasco

11

0 references

Javier Benitez

9

object named as

Javier Benitez

1 reference

3 January 2017

Sophie Badie

1

1 reference

3 January 2017

Jose M. Escandell

2

1 reference

3 January 2017

Peter Bouwman

3

1 reference

3 January 2017

Maria Thanasoula

5

1 reference

3 January 2017

Maria M. Gallardo

6

1 reference

3 January 2017

Anitha Suram

7

1 reference

3 January 2017

Isabel Jaco

8

1 reference

3 January 2017

Utz Herbig

10

1 reference

3 January 2017

Jos Jonkers

12

1 reference

3 January 2017

Madalena Tarsounas

13

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3 January 2017

language of work or name

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1 December 2010

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Nature Structural & Molecular Biology

3 January 2017

published in

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3 January 2017

volume

17

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3 January 2017

issue

12

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3 January 2017

page(s)

1461–1469

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

3 January 2017

cites work

1 reference

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RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation

20 March 2017

1 reference

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Telomere maintenance requires the RAD51D recombination/repair protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

20 March 2017

1 reference

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Molecular views of recombination proteins and their control

20 March 2017

1 reference

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20 March 2017

Chromosome fragile sites

1 reference

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Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Rad54 protein promotes branch migration of Holliday junctions

20 March 2017

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Cancer-susceptibility genes. Gatekeepers and caretakers

20 March 2017

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Involvement of Brca2 in DNA repair

20 March 2017

1 reference

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

20 March 2017

1 reference

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How shelterin protects mammalian telomeres

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

A DNA damage checkpoint response in telomere-initiated senescence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

DNA damage foci at dysfunctional telomeres

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Tumor spectrum analysis in p53-mutant mice

7 April 2017

1 reference

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p53 prevents entry into mitosis with uncapped telomeres

7 April 2017

1 reference

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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

29 September 2017

1 reference

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Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

29 September 2017

1 reference

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Replication fork arrest, recombination and the maintenance of ribosomal DNA stability

29 September 2017

1 reference

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Distinct roles of TRF1 in the regulation of telomere structure and lengthening

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Telomere uncapping and alternative lengthening of telomeres

29 September 2017

1 reference

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BRCA2: a universal recombinase regulator.

29 September 2017

1 reference

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Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

29 September 2017

1 reference

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Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

BRCA1 and BRCA2: 1994 and beyond

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Telomeres and the DNA damage response: why the fox is guarding the henhouse

29 September 2017

1 reference

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Role of mammalian Rad54 in telomere length maintenance

29 September 2017

1 reference

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The mammalian XRCC genes: their roles in DNA repair and genetic stability

29 September 2017

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Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

29 September 2017

1 reference

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Connecting chromosomes, crisis, and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Alternative lengthening of telomeres in mammalian cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

29 September 2017

1 reference

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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

BRCA2-dependent and independent formation of RAD51 nuclear foci.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998174

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

27 November 2018

1 reference

Semi-conservative DNA replication through telomeres requires Taz1

31 March 2020

1 reference

Telomeric proteins: clearing the way for the replication fork

31 March 2020

1 reference

TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.1943

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Dimensions Publication ID

1048897158

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1 reference

1 reference

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