Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects (Q36602578)

15 August 2017

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title

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects (English)

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15 August 2017

Evers B

1

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15 August 2017

Jonkers J

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 September 2006

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15 August 2017

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15 August 2017

25

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15 August 2017

5885-5897

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15 August 2017

43

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209871

15 August 2017

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cites work

BRCA1 regulates gene expression for orderly mitotic progression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA2-null embryonic survival is prolonged on the BALB/c genetic background.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Clinico-pathological characteristics of BRCA1- and BRCA2-related breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Paradoxical roles of the immune system during cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Identification of BRCA1-IRIS, a BRCA1 locus product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A new alternative splice variant of BRCA1 containing an additional in-frame exon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA1 mutations in primary breast and ovarian carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA1 supports XIST RNA concentration on the inactive X chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Conditional mouse models of sporadic cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

21 January 2018

Fibroblasts in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Cell-cycle checkpoints and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

21 January 2018

BRCA1 and transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA1 participates in DNA decatenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Tumorigenesis in mice carrying a truncating Brca1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca1 required for T cell lineage development but not TCR loci rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Collaboration of Brca1 and Chk2 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Expression of Brca1 and splice variant Brca1delta11 RNA levels in mouse mammary gland during normal development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca1 controls homology-directed DNA repair

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA1 and BRCA2: 1994 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Is BRCA1/BRCA2-related breast carcinogenesis estrogen dependent?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Involvement of Brca2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Emerging functions of BRCA2 in DNA recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Efficient BLG-Cre mediated gene deletion in the mammary gland.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Generation of a functional mammary gland from a single stem cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Generalized lacZ expression with the ROSA26 Cre reporter strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Repeated observation of breast tumor subtypes in independent gene expression data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Brca2 is required for embryonic cellular proliferation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Localization of BRCA1 and a splice variant identifies the nuclear localization signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Cre-mediated gene deletion in the mammary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Identification of the breast cancer susceptibility gene BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A delayed chemically induced tumorigenesis in Brca2 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Efficient Deletion of NormalBrca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

A role for Brca1 in chromosome end maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

Epidemiology, prevention, and early detection of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

p53 mutations in BRCA1-associated familial breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

Genomic instability in Gadd45a-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

Purification and unique properties of mammary epithelial stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

Mutations and alternative splicing of theBRCA1 gene in UK breast/ovarian cancer families

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209871

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209871

1 reference

release_n72y2cdnzzg2voun6lt67kjveu

15 August 2017

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24 November 2022

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