eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy (Q28118343)

4 January 2017

title

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy (English)

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positive regulation of polysome binding

4 January 2017

main subject

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negative regulation of polysome binding

GO:1905698

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regulation of eukaryotic translation initiation factor 4F complex assembly

GO:1905697

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negative regulation of eukaryotic translation initiation factor 4F complex assembly

GO:1905535

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regulation of polysome binding

GO:1905538

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positive regulation of eukaryotic translation initiation factor 4F complex assembly

GO:1905696

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Regulatory associated protein of MTOR complex 1

GO:1905537

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Eukaryotic translation initiation factor 4 gamma 2

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Eukaryotic translation initiation factor 4 gamma 1

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Eukaryotic translation initiation factor 4E

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Eukaryotic translation initiation factor 4 gamma 3

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positive regulation of G1/S transition of mitotic cell cycle

1 reference

1 reference

Francisco Ramírez-Valle

1

1 reference

4 January 2017

Steve Braunstein

2

1 reference

4 January 2017

Jiri Zavadil

3

1 reference

4 January 2017

Silvia C. Formenti

4

1 reference

4 January 2017

Robert J. Schneider

5

1 reference

4 January 2017

language of work or name

English

0 references

publication date

21 April 2008

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4 January 2017

published in

Journal of Cell Biology

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4 January 2017

volume

181

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4 January 2017

issue

2

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4 January 2017

page(s)

293–307

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p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins

4 January 2017

cites work

1 reference

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

20 March 2017

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Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

20 March 2017

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Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

20 March 2017

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Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

20 March 2017

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

20 March 2017

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20 March 2017

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Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast

20 March 2017

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TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function

20 March 2017

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Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I

20 March 2017

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

20 March 2017

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Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation

20 March 2017

1 reference

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Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

20 March 2017

1 reference

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

20 March 2017

1 reference

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20 March 2017

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22 April 2017

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7 April 2017

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Growing roles for the mTOR pathway

7 April 2017

1 reference

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Translational control in stress and apoptosis

7 April 2017

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7 April 2017

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

7 April 2017

1 reference

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7 April 2017

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A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

22 April 2017

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Ribosomal slowdown mediates translational arrest during cellular division.

29 September 2017

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Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog.

29 September 2017

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hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

29 September 2017

1 reference

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The eIF4G-homolog p97 can activate translation independent of caspase cleavage

29 September 2017

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Mitochondrial signaling, TOR, and life span

29 September 2017

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Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth

29 September 2017

1 reference

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Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53.

29 September 2017

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Specific isoforms of translation initiation factor 4GI show differences in translational activity

29 September 2017

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29 September 2017

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Identification of pathways regulating cell size and cell-cycle progression by RNAi

29 September 2017

1 reference

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

29 September 2017

1 reference

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KLF4, p21 and context-dependent opposing forces in cancer

29 September 2017

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Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation

29 September 2017

1 reference

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Macroautophagy versus mitochondrial autophagy: a question of fate?

29 September 2017

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Polypyrimidine tract-binding protein (PTB) inhibits Hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation, but does not affect HCV replication.

29 September 2017

1 reference

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29 September 2017

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Selective modification of eukaryotic initiation factor 4F (eIF4F) at the onset of cell differentiation: recruitment of eIF4GII and long-lasting phosphorylation of eIF4E.

29 September 2017

1 reference

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells

29 September 2017

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The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae

29 September 2017

1 reference

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Malignant transformation by overproduction of translation initiation factor eIF4G.

29 September 2017

1 reference

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29 September 2017

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2 June 2018

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2 June 2018

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Direct cleavage of elF4G by poliovirus 2A protease is inefficient in vitro

2 June 2018

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Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance

21 January 2018

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A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes

21 January 2018

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TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

21 January 2018

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https://api.crossref.org/works/10.1083%2FJCB.200710215

Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts.

21 January 2018

1 reference

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Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.

27 November 2018

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Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function

27 November 2018

1 reference

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200710215

1 reference

1 reference

1 reference

1 reference