Regulatory associated protein of MTOR complex 1 (Q21115067)

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mammalian protein found in Homo sapiens
  • regulatory-associated protein of mTOR
  • p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
  • raptor
  • p150 target of rapamycin (TOR)-scaffold protein
  • RPTOR
edit
Language Label Description Also known as
English
Regulatory associated protein of MTOR complex 1
mammalian protein found in Homo sapiens
  • regulatory-associated protein of mTOR
  • p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
  • raptor
  • p150 target of rapamycin (TOR)-scaffold protein
  • RPTOR

Statements

molecular function
protein binding
determination method
IPI
36 references
retrieved
1 January 2018
stated in
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Architecture of human mTOR complex 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Probing cellular protein complexes using single-molecule pull-down
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Rab1A is an mTORC1 activator and a colorectal oncogene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
retrieved
1 January 2018
stated in
The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IPI
cell component
TORC1 complex
determination method
IDA
IEA
6 references
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122
determination method
IEA
retrieved
31 October 2017
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
31 October 2017
stated in
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
31 October 2017
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
31 October 2017
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
31 October 2017
stated in
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122
determination method
IDA
TORC1 complex
determination method
IBA
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IEA
retrieved
1 January 2018
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
1 January 2018
stated in
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
1 January 2018
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
1 January 2018
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
1 January 2018
stated in
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
GOA
curator
UniProt
UniProt protein ID
Q8N122
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
D000076223
subject named as
Regulatory-Associated Protein of mTOR
0 references
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21115067&oldid=2022960599"