Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 (Q28139186)

1

0 references

R M Wolthuis

2

0 references

M F de Tand

3

0 references

I Janoueix-Lerosey

4

0 references

J L Bos

5

0 references

J de Gunzburg

Journal of Biological Chemistry

6

0 references

language of work or name

English

0 references

publication date

26 March 1999

0 references

published in

0 references

volume

274

0 references

issue

13

0 references

page(s)

8737-45

0 references

cites work

The GTPase superfamily: conserved structure and molecular mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Ras-dependent activation of the small GTPase Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

ralGDS family members interact with the effector loop of ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Identification of AF-6 and canoe as putative targets for Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Effects of the ras-related rap2 protein on cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Identification of a specific effector of the small GTP-binding protein Rap2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Stimulation of gene induction and cell growth by the Ras effector Rlf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Complex formation between RAS and RAF and other protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Identification of a protein associated with p21ras by chemical crosslinking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Activation of the small GTPase Ral in platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Physical association with ras enhances activation of membrane-bound raf (RafCAAX).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Identification and characterization of mutations in Ha-Ras that selectively decrease binding to cRaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

A mammalian scaffold complex that selectively mediates MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737

Ral and Rab3a are major GTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaptosomal exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.13.8737