The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction (Q28139281)

Progress in Biophysics and Molecular Biology

Europe PubMed Central

title

The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction (English)

0 references

1 reference

K L Craig

1

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M Tyers

series ordinal

2

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language of work or name

English

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publication date

1999

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published in

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volume

72

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issue

3

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page(s)

299-328

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cites work

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Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA.

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Cellular mechanisms of wingless/Wnt signal transduction

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The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

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The regulation of E2F by pRB-family proteins

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

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Identification of c-MYC as a target of the APC pathway

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Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

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7 January 2021

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

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7 January 2021

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7 January 2021

Twenty proteins containing a C-terminal SOCS box form five structural classes

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7 January 2021

Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome

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7 January 2021

Ubiquitin-dependent protein degradation

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7 January 2021

There's the rub: a novel ubiquitin-like modification linked to cell cycle regulation

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7 January 2021

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

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7 January 2021

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

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7 January 2021

Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA, genes controlling flower development in Arabidopsis and Antirrhinum

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7 January 2021

sud1(+) targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast

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7 January 2021

The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex

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7 January 2021

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

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7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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7 January 2021

Feasting, fasting and fermenting. Glucose sensing in yeast and other cells

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7 January 2021

The VHL tumour-suppressor gene paradigm

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7 January 2021

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.

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7 January 2021

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

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7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation

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7 January 2021

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

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7 January 2021

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

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7 January 2021

Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.

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7 January 2021

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

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7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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7 January 2021

The sulfur controller-2 negative regulatory gene of Neurospora crassa encodes a protein with beta-transducin repeats

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7 January 2021

An additional role for the F-box motif: gene regulation within the Neurospora crassa sulfur control network.

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7 January 2021

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

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7 January 2021

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex

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7 January 2021

Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation

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7 January 2021

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

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7 January 2021

UFO: an Arabidopsis gene involved in both floral meristem and floral organ development

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7 January 2021

Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1.

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7 January 2021

Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle

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7 January 2021

A novel protein modification pathway related to the ubiquitin system

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7 January 2021

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

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7 January 2021

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

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7 January 2021

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

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7 January 2021

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

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7 January 2021

A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

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7 January 2021

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

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7 January 2021

beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

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7 January 2021

Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

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7 January 2021

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins

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7 January 2021

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

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7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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7 January 2021

At least four regulatory genes control sulphur metabolite repression in Aspergillus nidulans

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7 January 2021

The Aspergillus nidulans sulphur regulatory gene sconB encodes a protein with WD40 repeats and an F-box.

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7 January 2021

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

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7 January 2021

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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7 January 2021

Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation

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7 January 2021

A new NEDD8-ligating system for cullin-4A

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7 January 2021

Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose

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7 January 2021

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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7 January 2021

A genetic framework for floral patterning.

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7 January 2021

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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7 January 2021

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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7 January 2021

Signaling through scaffold, anchoring, and adaptor proteins

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7 January 2021

Protein modules and signalling networks

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7 January 2021

Beta-catenin as oncogene: the smoking gun.

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7 January 2021

The oncogenic activation of beta-catenin

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7 January 2021

Transcription pattern of a FIM homologue in Impatiens during floral development and reversion

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7 January 2021

Function of the ubiquitin-proteosome pathway in auxin response

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7 January 2021

The ubiquitin-related protein RUB1 and auxin response in Arabidopsis.

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7 January 2021

Dynamics of proteasome distribution in living cells

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7 January 2021

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

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7 January 2021

Stabilization of beta-catenin by genetic defects in melanoma cell lines

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7 January 2021

The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p

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7 January 2021

Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer

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7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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7 January 2021

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

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7 January 2021

Linkage of replication to start by the Cdk inhibitor Sic1.

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

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7 January 2021

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

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7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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7 January 2021

Fimbriata controls flower development by mediating between meristem and organ identity genes.

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https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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7 January 2021

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

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7 January 2021

Negative regulation of the JAK/STAT pathway

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7 January 2021

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

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7 January 2021

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

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7 January 2021

Nuclear access and action of notch in vivo

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https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

A function for monoubiquitination in the internalization of a G protein-coupled receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Proteolytic ratchets that control progression through mitosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

One ring to rule a superfamily of E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

1 reference

7 January 2021

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Identification of a cullin homology region in a subunit of the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6107%2899%2900010-3

7 January 2021