AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter (Q28142631)

2

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Y Akbarali

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C J Hetherington

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J Boltax

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D A Yergeau

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D E Zhang

Journal of Biological Chemistry

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language of work or name

English

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publication date

27 August 1999

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published in

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volume

274

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issue

35

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page(s)

24671-6

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cites work

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Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

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PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells

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The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

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Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

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Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

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The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

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Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells

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Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases

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The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation

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Antigen receptors on B lymphocytes

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Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma

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Expression of protein tyrosine kinases in the Ig complex of anti-mu-sensitive and anti-mu-resistant B-cell lymphomas: role of the p55blk kinase in signaling growth arrest and apoptosis

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Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase

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The transcription factor NF-kappaB/p50 interacts with the blk gene during B cell activation

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A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation

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Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis

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The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

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NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation

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BSAP: a key regulator of B-cell development and differentiation

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An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene

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Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

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The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

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Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

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Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1

21 January 2018

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CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

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Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

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Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers

21 January 2018

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DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

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Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

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ETS-core binding factor: a common composite motif in antigen receptor gene enhancers

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Cooperative binding of Ets-1 and core binding factor to DNA

21 January 2018

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Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb

21 January 2018

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Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

21 January 2018

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Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma

21 January 2018

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

21 January 2018

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