ATM and ATR: networking cellular responses to DNA damage (Q28143424)

Current Opinion in Genetics & Development

Europe PubMed Central

title

ATM and ATR: networking cellular responses to DNA damage (English)

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Y Shiloh

1

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language of work or name

English

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publication date

February 2001

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published in

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volume

11

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page(s)

71-7

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issue

1

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cites work

Sensing and responding to DNA damage.

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ATM: a mediator of multiple responses to genotoxic stress

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

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Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

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The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells

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DNA damage induces phosphorylation of the amino terminus of p53

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Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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ATM associates with and phosphorylates p53: mapping the region of interaction

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Phosphorylation of p53 serine 15 increases interaction with CBP

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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The G2-phase DNA-damage checkpoint

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Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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GADD45 induction of a G2/M cell cycle checkpoint

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

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ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

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A role for ATR in the DNA damage-induced phosphorylation of p53

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

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BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

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Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase

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Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4

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Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

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Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl

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The controlling role of ATM in homologous recombinational repair of DNA damage

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Nijmegen breakage syndrome: consequences of defective DNA double strand break repair

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The Mre11 complex and ATM: collaborating to navigate S phase

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A mechanistic basis for Mre11-directed DNA joining at microhomologies

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins

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Linking DNA damage and neurodegeneration

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c-Abl: activation and nuclear targets

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

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p73: structure and function

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Substrate specificities and identification of putative substrates of ATM kinase family members

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7 January 2021

Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

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7 January 2021

Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity

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Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

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Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

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7 January 2021

Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation

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Localization of a portion of extranuclear ATM to peroxisomes

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ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.

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7 January 2021

10.1016/S0959-437X(00)00159-3

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

4462624

4462624

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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