Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8) (Q28144264)

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A Mally

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L T Elliott

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S Meyers

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

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language of work or name

English

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publication date

27 July 2000

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published in

Oncogene

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volume

19

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issue

32

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page(s)

3584-97

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cites work

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Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

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CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family

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High-efficiency transformation of mammalian cells by plasmid DNA

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Identification of the human c-myc protein nuclear translocation signal

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ETO-2, a new member of the ETO-family of nuclear proteins.

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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Nuclear targeting sequences--a consensus?

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

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Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

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Nucleocytoplasmic transport

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Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

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Isolation of a protein that is essential for the first step of nuclear protein import

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Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies.

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The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

21 January 2018

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Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.

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Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family

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Structure and Function in the Nucleus

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AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter

21 January 2018

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

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The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor

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Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

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Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

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Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.

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Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes

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Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor

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Nucleocytoplasmic transport: signals, mechanisms and regulation

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Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia

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NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence

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Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells

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Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1

21 January 2018

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The green fluorescent protein

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ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

21 January 2018

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

21 January 2018

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Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

21 January 2018

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RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.

21 January 2018

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The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

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Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

21 January 2018

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CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

21 January 2018

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The importance of importin

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7 January 2021

Sequence specificity of the core-binding factor

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7 January 2021

Indirect and direct disruption of transcriptional regulation in cancer: E2F and AML-1.

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7 January 2021

Associations between distinct pre-mRNA splicing components and the cell nucleus

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7 January 2021