The INK4 family of cell cycle inhibitors in cancer (Q28145080)

Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma

Europe PubMed Central

title

The INK4 family of cell cycle inhibitors in cancer (English)

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author name string

M F Roussel

series ordinal

1

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language of work or name

English

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publication date

20 September 1999

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published in

Oncogene

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volume

18

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issue

38

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page(s)

5311-7

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cites work

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

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Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

21 January 2018

1 reference

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

The regulation of E2F by pRB-family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

The cell cycle and the retinoblastoma protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Cdk inhibitors in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Germline p16 mutations in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Interaction between Cdc37 and Cdk4 in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Growth suppression by p16ink4 requires functional retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Mutations associated with familial melanoma impair p16INK4 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

The INK4A/ARF locus and its two gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Spatial control of coated-pit dynamics in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

7 January 2021

The ins and outs of RB: coupling gene expression to the cell cycle clock

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202998

7 January 2021