Diverse nuclear transport pathways regulate cell proliferation and oncogenesis (Q28145134)

Biochimica et Biophysica Acta

Europe PubMed Central

title

Diverse nuclear transport pathways regulate cell proliferation and oncogenesis (English)

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author name string

J K Hood

series ordinal

1

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P A Silver

series ordinal

2

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language of work or name

English

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publication date

31 July 2000

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published in

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volume

1471

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issue

1

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page(s)

M31-41

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cites work

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A short amino acid sequence able to specify nuclear location

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Identification of a signal for rapid export of proteins from the nucleus

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hnRNP proteins: localization and transport between the nucleus and the cytoplasm

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A novel class of RanGTP binding proteins

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Transport between the cell nucleus and the cytoplasm

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Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex

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7 January 2021

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

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7 January 2021

The yeast nuclear pore complex: composition, architecture, and transport mechanism

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A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif

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7 January 2021

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

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7 January 2021

A GTPase controlling nuclear trafficking: running the right way or walking RANdomly?

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7 January 2021

RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae

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7 January 2021

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport

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7 January 2021

Catalysis of guanine nucleotide exchange of Ran by RCC1 and stimulation of hydrolysis of Ran-bound GTP by Ran-GAP1.

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7 January 2021

CRM1 is an export receptor for leucine-rich nuclear export signals

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7 January 2021

Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor

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7 January 2021

Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae

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7 January 2021

Cse1p is involved in export of yeast importin alpha from the nucleus

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7 January 2021

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

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7 January 2021

Functional domains in nuclear import factor p97 for binding the nuclear localization sequence receptor and the nuclear pore

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7 January 2021

The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein

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7 January 2021

Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting

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7 January 2021

NTF2 mediates nuclear import of Ran.

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7 January 2021

Nuclear import of Ran is mediated by the transport factor NTF2.

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7 January 2021

beta-catenin can be transported into the nucleus in a Ran-unassisted manner

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7 January 2021

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

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7 January 2021

Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway

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7 January 2021

An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins

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7 January 2021

Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta

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7 January 2021

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Transport pathways of macromolecules between the nucleus and the cytoplasm.

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Transport routes through the nuclear pore complex

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Distinct functions for the two importin subunits in nuclear protein import

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7 January 2021

The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

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7 January 2021

The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor

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7 January 2021

Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

The nucleoporin nup153 plays a critical role in multiple types of nuclear export

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7 January 2021

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast

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7 January 2021

Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

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7 January 2021

Structure of importin-beta bound to the IBB domain of importin-alpha

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7 January 2021

Structural view of the Ran-Importin beta interaction at 2.3 A resolution

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7 January 2021

Nuclear targeting sequences--a consensus?

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Exportin 1 (Crm1p) is an essential nuclear export factor

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

A nuclear localization domain in the hnRNP A1 protein

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Definition of a consensus transportin-specific nucleocytoplasmic transport signal

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

A novel receptor-mediated nuclear protein import pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

In or out? Regulating nuclear transport

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Roles of phosphorylation sites in regulating activity of the transcription factor Pho4.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

The N-terminal domain of IkappaB alpha masks the nuclear localization signal(s) of p50 and c-Rel homodimers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

MPF localization is controlled by nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Twenty years of p53 research: structural and functional aspects of the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Regulation of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Mechanisms of switching on p53: a role for covalent modification?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

How regulated protein translocation can produce switch-like responses

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

SAPKs and transcription factors do the nucleocytoplasmic tango

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021

Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900018-4

7 January 2021