MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts (Q28200748)

4

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Fabiola Moretti

7

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Francesca Gentiletti

1

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Francesca Mancini

2

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author name string

Francesca Gentiletti

1

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Marco D'Angelo

3

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Alfredo Pontecorvi

5

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Aart G Jochemsen

New de-ubiquitinating enzyme, ubiquitin C-terminal hydrolase 8, in chick skeletal muscle

6

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language of work or name

English

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publication date

31 January 2002

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published in

Oncogene

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volume

21

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issue

6

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page(s)

867-77

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cites work

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SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

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Mapping of the p53 and mdm-2 interaction domains

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Proteolytic cleavage of the mdm2 oncoprotein during apoptosis

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.

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Mdm2 promotes the rapid degradation of p53

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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Constitutive mdmx expression during cell growth, differentiation, and DNA damage

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MdmX protects p53 from Mdm2-mediated degradation

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MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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Interpreting cDNA sequences: some insights from studies on translation

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Regulation of p53 stability by Mdm2

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The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells.

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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The G(2) checkpoint is maintained by redundant pathways

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p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53.

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Activation of an MDM2-specific caspase by p53 in the absence of apoptosis

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

21 January 2018

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p53 associates with and targets Delta Np63 into a protein degradation pathway

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

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Differential responses of proliferating versus quiescent cells to adriamycin

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DNA damage induces phosphorylation of the amino terminus of p53

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Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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Kinetics of p53 binding to promoter sites in vivo

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MDM2 interacts with MDMX through their RING finger domains

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Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules

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Suicidal tendencies: apoptotic cell death by caspase family proteinases

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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mdm2 expression is induced by wild type p53 activity

21 January 2018

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7 January 2021

Comparative study of the p53-mdm2 and p53-MDMX interfaces

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7 January 2021

A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells

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7 January 2021

Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light

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7 January 2021