The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription (Q28206541)

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scientific article (publication date: 2002)

The Von Hippel—Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription

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English	The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription	scientific article (publication date: 2002)	The Von Hippel—Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription

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The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription (English)

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The Von Hippel—Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription (English)

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Joan W. Conaway

object named as

Joan W. Conaway

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author name string

Ronald C Conaway

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Joan W Conaway

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Ronald C. Conaway

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publication date

2002

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Advances in Cancer Research

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85

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1-12

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The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

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The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex

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Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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A conserved family of prolyl-4-hydroxylases that modify HIF

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VACM-1, a cullin gene family member, regulates cellular signaling

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E

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SCF and Cullin/Ring H2-based ubiquitin ligases

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Inhibition of transcription elongation by the VHL tumor suppressor protein

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans

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Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

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Mutations of the VHL tumour suppressor gene in renal carcinoma

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

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Identification of the von Hippel-Lindau disease tumor suppressor gene

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Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

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7 January 2021

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

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7 January 2021

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

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7 January 2021

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

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7 January 2021

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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7 January 2021

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Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

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7 January 2021

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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7 January 2021

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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis

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Perspectives on oxygen sensing

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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7 January 2021

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Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

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7 January 2021

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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7 January 2021

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

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7 January 2021

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

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https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2985001-1

7 January 2021

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

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Identification of a cullin homology region in a subunit of the anaphase-promoting complex

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Signal transduction. How do cells sense oxygen?

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10.1016/S0065-230X(02)85001-1

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