Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil (Q28208559)

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10 November 2019

title

Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil (English)

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10 November 2019

1 reference

1

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10 November 2019

Boris Kopnin

4

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10 November 2019

Peter M. Chumakov

6

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10 November 2019

author name string

Alexey V Ivanov

2

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10 November 2019

Julia E Kravchenko

3

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10 November 2019

Arnold J Levine

5

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10 November 2019

language of work or name

English

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publication date

1 July 2002

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10 November 2019

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10 November 2019

volume

21

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10 November 2019

page(s)

4595-4600

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10 November 2019

issue

30

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p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas

10 November 2019

cites work

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Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.

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Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

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Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

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Gain of function mutations in p53.

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Regulation of p53 downstream genes.

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

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7 January 2021

Changes in p53 expression can modify cell shape of ras-transformed fibroblasts and epitheliocytes.

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

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Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene

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7 January 2021

'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

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7 January 2021

p53, the cellular gatekeeper for growth and division

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7 January 2021

The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype

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7 January 2021

Mutant p53 protein expression interferes with p53-independent apoptotic pathways.

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7 January 2021

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7 January 2021

High metastatic potential in mice inheriting a targeted p53 missense mutation

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7 January 2021

A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity

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7 January 2021

The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis

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7 January 2021

p53 mutations: gains or losses?

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7 January 2021

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

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7 January 2021

Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma

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7 January 2021

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.

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7 January 2021

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

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7 January 2021

The influence of the p53 gene on the in vitro chemosensitivity of colorectal cancer cells.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205704

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12096336%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

0 references

1 reference

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